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Mouse Anti-UVRAG (aa 260-360) Recombinant Antibody (CBLXU-001) (CBMAB-U0004-CQ)

This product is a mouse antibody that recognizes UVRAG (aa 260-360). The antibody CBLXU-001 can be used for immunoassay techniques such as: FC, CyTOF.
See all UVRAG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLXU-001
Antibody Isotype
IgG1
Application
FC, CyTOF

Basic Information

Immunogen
Human UVRAG synthetic peptide corresponding to amino acids 260-360
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 260-360

Target

Full Name
UV Radiation Resistance Associated
Introduction
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Diseases associated with UVRAG include Ascending Colon Cancer and Cholecystolithiasis. Among its related pathways are DNA Damage and Autophagy Pathway.
Entrez Gene ID
7405
UniProt ID
Q9P2Y5
Alternative Names
UVRAG; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; beclin 1 binding protein; VPS38; disrupted in heterotaxy; p63; DHTX
Function
Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502).
During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502).
Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303).
Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502).
Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300).
In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).
Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840).
Required for centrosome stability and proper chromosome segregation (PubMed:22542840).
Biological Process
Biological Process autophagosome maturation Source:UniProtKB1 Publication
Biological Process autophagy Source:CACAO1 Publication
Biological Process centrosome cycle Source:UniProtKB1 Publication
Biological Process chromosome segregation Source:Ensembl
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process double-strand break repair via classical nonhomologous end joining Source:UniProtKB1 Publication
Biological Process maintenance of Golgi location Source:CACAO1 Publication
Biological Process multivesicular body sorting pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process phosphatidylinositol-3-phosphate biosynthetic process Source:ComplexPortal1 Publication
Biological Process positive regulation of autophagosome maturation Source:ParkinsonsUK-UCL1 Publication
Biological Process protein phosphorylation Source:ComplexPortal1 Publication
Biological Process receptor catabolic process Source:UniProtKB1 Publication
Biological Process regulation of autophagy Source:ComplexPortal1 Publication
Biological Process regulation of cytokinesis Source:UniProtKB1 Publication
Biological Process regulation of protein serine/threonine kinase activity Source:UniProtKB1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source:CACAO1 Publication
Biological Process SNARE complex assembly Source:GO_Central1 Publication
Biological Process spindle organization Source:Ensembl
Biological Process viral entry into host cell Source:Ensembl
Cellular Location
Late endosome
Lysosome
Cytoplasmic vesicle, autophagosome
Early endosome
Endoplasmic reticulum
Midbody
Chromosome, centromere
Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303).
Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502).
Involvement in disease
A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).
PTM
Phosphorylated at Ser-498 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7,A and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (PubMed:25533187).
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For research use only. Not intended for any clinical use.

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