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Mouse Anti-VAX1 Recombinant Antibody (CBYY-1309) (CBMAB-1329-YY)

This product is mouse antibody that recognizes VAX1. The antibody CBYY-1309 can be used for immunoassay techniques such as: ELISA, WB
See all VAX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rabbit
Clone
CBYY-1309
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from human VAX1 (NP_954582) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Mouse, Rabbit
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ventral anterior homeobox 1
Introduction
This gene encodes a homeo-domain containing protein from a class of homeoBovinex transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of Bovinedy development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeoBovinex gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
Human11023
Mouse22326
Rabbit100351281
UniProt ID
HumanQ5SQQ9
MouseQ2NKI2
RabbitG1T5K8
Alternative Names
Ventral Anterior HomeoBovinex 1; MCOPS11;
Function
Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).
Biological Process
Biological Process astrocyte differentiation Source:Ensembl
Biological Process axon guidance Source:Ensembl
Biological Process brain development Source:Ensembl
Biological Process camera-type eye development Source:Ensembl
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process negative regulation of neuroblast proliferation Source:Ensembl
Biological Process neuroblast proliferation Source:Ensembl
Biological Process neuroepithelial cell differentiation Source:Ensembl
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process neuron migration Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process roof of mouth development Source:Ensembl
Biological Process skeletal muscle cell differentiation Source:Ensembl
Cellular Location
Nucleus
Involvement in disease
Microphthalmia, syndromic, 11 (MCOPS11):
A rare clinical entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum, hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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