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Mouse Anti-VHL Recombinant Antibody (P52A11AT) (CBMAB-V0242-LY)

This product is antibody recognizes VHL. The antibody P52A11AT immunoassay techniques such as: ELISA, WB.
Host Species
Mouse
Application
ELISA, WB
Immunogen
Anti-human VHL mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human VHL AA 1-154
Antibody Isotype
IgG
Specificity
Human
Clone
P52A11AT
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Alternative Name
Von Hippel-Lindau Tumor Suppressor; Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase; Protein G7; PVHL; Von Hippel-Lindau Disease Tumor Suppressor; Von Hippel-Lindau Syndrome;
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-V0242-LY
Conjugates
Size
Price $
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Second antibody and isotype control