Mouse Anti-VPS13B Recombinant Antibody (OTI6D1) (CBMAB-V0231-LY)

Name: Mouse Anti-VPS13B Recombinant Antibody (OTI6D1)
SKU: CBMAB-V0231-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

OTI6D1

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 91-346 of human VPS13B(NP_858047) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

vacuolar protein sorting 13B

Introduction

This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

157680

UniProt ID

Q7Z7G8

Alternative Names

Vacuolar Protein Sorting 13 Homolog B; CHS1; COH1; Vacuolar Protein Sorting-Associated Protein 13B; Vacuolar Protein Sorting 13 Homolog B (Yeast); Cohen Syndrome Protein 1; Cohen Syndrome 1; KIAA0532;

Function

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity).
Binds phosphatidylinositol 3-phosphate (By similarity).
Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:30962439, PubMed:24334764, PubMed:32375900).
Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity).
Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173).
Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273).
May also play a role during adipose tissue development (PubMed:26358774).
Required for maintenance of the ocular lens (By similarity).

Biological Process

Biological Process acrosome assembly Source:UniProtKB
Biological Process adipose tissue development Source:UniProtKB1 Publication
Biological Process central nervous system development Source:UniProtKB
Biological Process Golgi organization Source:UniProtKB1 Publication
Biological Process Golgi reassembly Source:UniProtKB
Biological Process lipid transport Source:UniProtKB-KW
Biological Process maintenance of lens transparency Source:UniProtKB
Biological Process nervous system development Source:UniProtKB1 Publication
Biological Process neuron projection development Source:UniProtKB1 Publication
Biological Process slow endocytic recycling Source:UniProtKB1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB1 Publication

Cellular Location

Recycling endosome membrane
Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Golgi apparatus, cis-Golgi network membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus, trans-Golgi network membrane
Early endosome membrane
Lysosome membrane
Localizes to proacrosomal and acrosomal vesicles and not the Golgi apparatus during acrosome formation.

Involvement in disease

Cohen syndrome (COH1):
A rare autosomal recessive disorder characterized by obesity, hypotonia, intellectual deficit, characteristic craniofacial dysmorphism and abnormalities of the hands and feet. Characteristic facial features include high-arched or wave-shaped eyelids, a short philtrum, thick hair and low hairline.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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