Mouse Anti-VPS50 (AA 862-964) Recombinant Antibody (CBXF-3302) (CBMAB-F3996-CQ)

Name: Mouse Anti-VPS50 (AA 862-964) Recombinant Antibody (CBXF-3302)
SKU: CBMAB-F3996-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXF-3302

Application

ELISA, WB

Immunogen

FLJ20097 (NP_060137, 862aa-964aa) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 862-964

More Infomation

Target

Full Name

VPS50, EARP/GARPII Complex Subunit

Introduction

VPS50 (VPS50, EARP/GARPII Complex Subunit) is a Protein Coding gene.

Entrez Gene ID

55610

UniProt ID

Q96JG6

Alternative Names

VPS50, EARP/GARPII Complex Subunit; Coiled-Coil Domain-Containing Protein 132; Coiled-Coil Domain Containing 132; EARP/GARPII Complex Subunit VPS50; Syndetin; CCDC132; KIAA1861; VPS54L;

Function

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

Biological Process

Biological Process endocytic recycling Source:MGI1 Publication
Biological Process protein transport Source:UniProtKB-KW

Cellular Location

Recycling endosome
Membrane
Associates with membranes in an EIPR1-dependent manner.

Involvement in disease

Neurodevelopmental disorder with microcephaly, seizures, and neonatal cholestasis (NEDMSC):
An autosomal recessive disorder with onset at birth, characterized by severe global developmental delay, profoundly impaired intellectual development, progressive microcephaly, seizures, and transient neonatal cholestasis. Brain imaging shows agenesis or hypoplasia of the corpus callosum. Death in early childhood may occur.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-VPS50 Recombinant Antibody (2D11) (CAT#: CBMAB-C4857-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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