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Mouse Anti-VRK3 Recombinant Antibody (C-8) (CBMAB-V0064-YC)

Provided herein is a Mouse monoclonal antibody against Human VRK3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all VRK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C-8
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vaccinia Related Kinase 3
Introduction
VRK3 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, VRK3 has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. VRK3 is widely expressed in human tissues and its protein localizes to the nucleus.
Entrez Gene ID
Human51231
Mouse101568
Rat361565
UniProt ID
HumanQ8IV63
MouseQ8K3G5
RatQ66HC2
Alternative Names
Vaccinia Related Kinase 3; Serine/Threonine-Protein Pseudokinase VRK3; Vaccinia-Related Kinase 3
Function
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.
Biological Process
Biological Process negative regulation of ERK1 and ERK2 cascade Source:Ensembl
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of phosphoprotein phosphatase activity Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process skeletal muscle tissue development Source:FlyBase1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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