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Mouse Anti-WARS2 Recombinant Antibody (CBYY-1613) (CBMAB-1684-YY)

This product is mouse antibody that recognizes WARS2. The antibody CBYY-1613 can be used for immunoassay techniques such as: ELISA
See all WARS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1613
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
WARS2 (NP_056651.1, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MALHSMRKAR ERWSFIRALH KGSAAAPALQ KDSKKRVFSG IQPTGILHLG NYLGAIESWV RLQDEYDSVL YSIVDLHSIT VPQDPAVLRQ
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tryptophanyl tRNA synthetase 2, mitochondrial
Introduction
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forMouse of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforMouse have been described.
Entrez Gene ID
10352
UniProt ID
Q9UGM6
Alternative Names
Tryptophanyl TRNA Synthetase 2, Mitochondrial; Tryptophan TRNA Ligase 2, Mitochondrial; EC 6.1.1.2; (Mt)TrpRS; TrpRS; Tryptophan--TRNA Ligase, Mitochondrial; Tryptophanyl-TRNA Synthetase; EC 6.1.1; NEMMLAS;
Function
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
Biological Process
Biological Process mitochondrial tryptophanyl-tRNA aminoacylation Source:GO_Central1 Publication
Biological Process positive regulation of angiogenesis Source:Ensembl
Biological Process tRNA aminoacylation for protein translation Source:Reactome
Biological Process tryptophanyl-tRNA aminoacylation Source:GO_Central1 Publication
Biological Process vasculogenesis Source:Ensembl
Cellular Location
Mitochondrion matrix
Involvement in disease
Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS):
An autosomal recessive, mitochondrial disorder with a broad phenotypic spectrum ranging from severe neonatal lactic acidosis, encephalomyopathy and early death to an attenuated course with milder manifestations. Clinical features include delayed psychomotor development, intellectual disability, hypotonia, dystonia, ataxia, and spasticity. Severe combined respiratory chain deficiency may be found in severely affected individuals.
Parkinsonism-dystonia 3, childhood-onset (PKDYS3):
An autosomal recessive neurodegenerative disorder with onset in infancy or early childhood. Affected individuals present with progressive movement abnormalities, including parkinsonism with tremor, dystonia, myoclonus ataxia, and hyperkinetic movements such as ballismus. The parkinsonism features may be responsive to treatment with levodopa, although many patients develop levodopa-induced dyskinesia. Some patients may have mild cognitive impairment or psychiatric disturbances.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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