Rat Anti-WDR1 Recombinant Antibody (CBYY-1599) (CBMAB-1670-YY)

Name: Rat Anti-WDR1 Recombinant Antibody (CBYY-1599)
SKU: CBMAB-1670-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBYY-1599

Application

Specificity

Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WD repeat domain 1

Introduction

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforMouse have been found for this gene.

Entrez Gene ID

22388

UniProt ID

O88342

Alternative Names

WD Repeat Domain 1; Actin-Interacting Protein 1; NORI-1; AIP1; Epididymis Secretory Protein Li 52; WD Repeat-Containing Protein 1; HEL-S-52;

Function

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004).
Enhances cofilin-mediated actin severing (By similarity).
Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608).
Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity).
Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity).
Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).

Biological Process

Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process actin filament fragmentation Source:Ensembl
Biological Process apical junction assembly Source:UniProtKB1 Publication
Biological Process cortical cytoskeleton organization Source:Ensembl
Biological Process establishment of planar polarity of follicular epithelium Source:Ensembl
Biological Process locomotion Source:GO_Central1 Publication
Biological Process maintenance of epithelial cell apical/basal polarity Source:UniProtKB1 Publication
Biological Process neutrophil mediated immunity Source:Ensembl
Biological Process neutrophil migration Source:Ensembl
Biological Process platelet formation Source:Ensembl
Biological Process positive regulation of actin filament depolymerization Source:GO_Central1 Publication
Biological Process regulation of actin filament depolymerization Source:UniProtKB1 Publication
Biological Process regulation of cell shape Source:Ensembl
Biological Process regulation of oligodendrocyte differentiation Source:Ensembl
Biological Process regulation of ventricular cardiac muscle cell membrane repolarization Source:Ensembl
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process sensory perception of sound Source:ProtInc1 Publication

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Cell projection, podosome
Cell junction

Involvement in disease

Periodic fever, immunodeficiency, and thrombocytopenia syndrome (PFITS):
An immunologic disorder with variable manifestations including early-onset recurrent respiratory infections, stomatitis, cutaneous infections, and neutropenia.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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