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Rat Anti-WDR1 Recombinant Antibody (CBYY-1599) (CBMAB-1670-YY)

This product is rat antibody that recognizes WDR1. The antibody CBYY-1599 can be used for immunoassay techniques such as: WB
See all WDR1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-1599
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD repeat domain 1
Introduction
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
22388
UniProt ID
O88342
Alternative Names
WD Repeat Domain 1; Actin-Interacting Protein 1; NORI-1; AIP1; Epididymis Secretory Protein Li 52; WD Repeat-Containing Protein 1; HEL-S-52;
Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004).
Enhances cofilin-mediated actin severing (By similarity).
Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608).
Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity).
Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity).
Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
Biological Process
Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process actin filament fragmentation Source:Ensembl
Biological Process apical junction assembly Source:UniProtKB1 Publication
Biological Process cortical cytoskeleton organization Source:Ensembl
Biological Process establishment of planar polarity of follicular epithelium Source:Ensembl
Biological Process locomotion Source:GO_Central1 Publication
Biological Process maintenance of epithelial cell apical/basal polarity Source:UniProtKB1 Publication
Biological Process neutrophil mediated immunity Source:Ensembl
Biological Process neutrophil migration Source:Ensembl
Biological Process platelet formation Source:Ensembl
Biological Process positive regulation of actin filament depolymerization Source:GO_Central1 Publication
Biological Process regulation of actin filament depolymerization Source:UniProtKB1 Publication
Biological Process regulation of cell shape Source:Ensembl
Biological Process regulation of oligodendrocyte differentiation Source:Ensembl
Biological Process regulation of ventricular cardiac muscle cell membrane repolarization Source:Ensembl
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process sensory perception of sound Source:ProtInc1 Publication
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Cell projection, podosome
Cell junction
Involvement in disease
Periodic fever, immunodeficiency, and thrombocytopenia syndrome (PFITS):
An immunologic disorder with variable manifestations including early-onset recurrent respiratory infections, stomatitis, cutaneous infections, and neutropenia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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