Mouse Anti-WDR41 Recombinant Antibody (1F3) (CBMAB-W0047-WJ)

Name: Mouse Anti-WDR41 Recombinant Antibody (1F3)
SKU: CBMAB-W0047-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1F3

Application

ELISA, WB

Immunogen

WDR41 (AAH40241, aa1-459) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WD repeat domain 41

Introduction

WDR41 is a protein-coding gene. The diseases associated with WDR41 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 and Amyotrophic Lateral Sclerosis 1.

Entrez Gene ID

55255

UniProt ID

Q9HAD4

Alternative Names

MSTP048

Function

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531).
The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069).
As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654).
The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).

Biological Process

Biological Process autophagy Source:UniProtKB-KW
Biological Process negative regulation of exocytosis Source:ComplexPortal1 Publication
Biological Process negative regulation of immune response Source:ComplexPortal1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of autophagy Source:UniProtKB1 Publication

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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