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Mouse Anti-WDR41 Recombinant Antibody (1F3) (CBMAB-W0047-WJ)

This product is a mouse antibody that recognizes WDR41. The antibody 1F3 can be used for immunoassay techniques such as: ELISA, WB.
See all WDR41 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F3
Antibody Isotype
IgG2b, Κ
Application
ELISA, WB

Basic Information

Immunogen
WDR41 (AAH40241, aa1-459) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD repeat domain 41
Introduction
WDR41 is a protein-coding gene. The diseases associated with WDR41 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 and Amyotrophic Lateral Sclerosis 1.
Entrez Gene ID
55255
UniProt ID
Q9HAD4
Alternative Names
MSTP048
Function
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531).
The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069).
As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654).
The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process negative regulation of exocytosis Source:ComplexPortal1 Publication
Biological Process negative regulation of immune response Source:ComplexPortal1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of autophagy Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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