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Mouse Anti-DCAF8 Recombinant Antibody (4G8) (CBMAB-A9921-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G8
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
WDR42A full-length recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent

Target

Full Name
DDB1 And CUL4 Associated Factor 8
Entrez Gene ID
50717
UniProt ID
Q5TAQ9
Function
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Biological Process
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Nucleus; Cytoplasm. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.
Involvement in disease
Giant axonal neuropathy 2, autosomal dominant (GAN2):
An autosomal dominant peripheral axonal neuropathy characterized by onset of distal sensory impairment with lower extremity muscle weakness and atrophy after the second decade. Clinical features include foot deformities apparent in childhood, and cardiomyopathy in severely affected individuals. Sural nerve biopsy shows giant axonal swelling with neurofilament accumulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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