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Mouse Anti-DCAF8 Recombinant Antibody (4G8) (CBMAB-A9921-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
4G8
Application
ELISA, IF, WB
Immunogen
WDR42A full-length recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
More Infomation

Target

Full Name
DDB1 And CUL4 Associated Factor 8
Entrez Gene ID
50717
UniProt ID
Q5TAQ9
Function
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Biological Process
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Nucleus; Cytoplasm. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.
Involvement in disease
Giant axonal neuropathy 2, autosomal dominant (GAN2):
An autosomal dominant peripheral axonal neuropathy characterized by onset of distal sensory impairment with lower extremity muscle weakness and atrophy after the second decade. Clinical features include foot deformities apparent in childhood, and cardiomyopathy in severely affected individuals. Sural nerve biopsy shows giant axonal swelling with neurofilament accumulation.

Huang, Y. H., Chen, C. W., Sundaramurthy, V., Słabicki, M., Hao, D., Watson, C. J., ... & Goodell, M. A. (2022). Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor. Cancer Discovery, 12(1), 220-235.

Nowak, M., Suenkel, B., Porras, P., Migotti, R., Schmidt, F., Kny, M., ... & Sommer, T. (2019). DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Journal of cell science, 132(17), jcs233395.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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