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Mouse Anti-THOC6 Recombinant Antibody (1F6) (CBMAB-A9924-LY)

The product is antibody recognizes WDR58. The antibody 1F6 immunoassay techniques such as: WB, ELISA.
See all THOC6 antibodies
Published Data
Fig.1 Thoc5 interacts with pre-mRNA cleavage and polyadenylation factors.
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Fig.2 Total cell extracts prepared from the cells were subjected to western blot using the indicated antibodies.
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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1F6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
WDR58 (NP_077315, 71 a.a. ~ 180 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
THO Complex 6
Entrez Gene ID
Human79228
Rat79227
UniProt ID
HumanQ86W42
RatQ6AY87
Alternative Names
MGC2655; WDR58; fSAP35
Function
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
Biological Process
Biological Process apoptotic processSource:UniProtKB-KW
Biological Process central nervous system developmentSource:UniProtKB1 Publication
Biological Process mRNA export from nucleusSource:UniProtKB1 Publication
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process negative regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process RNA splicingSource:UniProtKB-KW
Biological Process viral mRNA export from host cell nucleusSource:UniProtKB1 Publication
Cellular Location
Nucleus
Nucleus speckle
Involvement in disease
Beaulieu-Boycott-Innes syndrome (BBIS):
An autosomal recessive neurodevelopmental disorder characterized by delayed development, moderate intellectual disability, and dysmorphic facial features. Other developmental anomalies, such as cardiac and renal defects, may also occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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