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Mouse Anti-WDR62 Recombinant Antibody (CBWJW-168) (CBMAB-W0311-WJ)

This product is a mouse antibody that recognizes WDR62. The antibody CBWJW-168 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all WDR62 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJW-168
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD repeat domain 62
Introduction
WDR62 is a protein-coding gene. This gene is proposed to play a role in cerebral cortical development. Diseases associated with WDR62 include Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations and Second-Degree Atrioventricular Block. MAPKBP1 is an important paralog of this gene.
Entrez Gene ID
284403
UniProt ID
O43379
Alternative Names
MCPH2; C19orf14
Function
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831).
Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Biological Process
Biological Process centriole replication Source:UniProtKB1 Publication
Biological Process cerebral cortex development Source:UniProtKB1 Publication
Biological Process mitotic spindle organization Source:MGI1 Publication
Biological Process neurogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of neuroblast proliferation Source:Ensembl
Biological Process positive regulation of neuron migration Source:Ensembl
Biological Process regulation of centrosome cycle Source:Ensembl
Biological Process regulation of neuron differentiation Source:Ensembl
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, spindle pole
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles.
Involvement in disease
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2):
A disease characterized by microcephaly, moderate to severe intellectual disability, and various type of cortical malformations in most patients. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Cortical malformations include pachygyria with cortical thickening, microgyria, lissencephaly, hypoplasia of the corpus callosum, schizencephaly. All affected individuals have delayed psychomotor development. Some patients have seizures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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