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Mouse Anti-WDR73 Recombinant Antibody (4A6) (CBMAB-A9927-LY)

The product is antibody recognizes WDR73. The antibody 4A6 immunoassay techniques such as: WB, ELISA.
See all WDR73 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
WDR73 (NP_116245.2, 1 a.a. ~ 378 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WD repeat domain 73
Entrez Gene ID
84942
UniProt ID
Q6P4I2
Alternative Names
FLJ14888; HSPC264
Function
May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283).
Biological Process
Biological Process cytoplasmic microtubule organization Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process nucleus organization Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
Cleavage furrow
During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow.
Involvement in disease
Galloway-Mowat syndrome 1 (GAMOS1):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Patients may die in early childhood. GAMOS1 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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