Rat Anti-WNT4 Recombinant Antibody (CBWJW-128) (CBMAB-W0277-WJ)

Rat

Human, Mouse

CBWJW-128

IgG2a

ELISA, WB

Recombinant corresponding to aa37-76 from mouse Wnt-4, expressed in E. coli.

Human, Mouse

IgG2a

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Lyophilized

0.5 mg/mL

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Wnt family member 4

WNT4 is a protein-coding gene encodes the proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Diseases associated with WNT4 include 46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs and Mullerian Aplasia And Hyperandrogenism. An important paralog of this gene is WNT5A.

Wnt family member 4

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450).
Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity).
Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450).
Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450).
Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity).

Biological Process adrenal gland development Source:UniProtKB1 Publication
Biological Process apoptotic signaling pathway Source:Ensembl
Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:UniProtKB3 Publications
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to starvation Source:Ensembl
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process embryonic epithelial tube formation Source:Ensembl
Biological Process epithelial to mesenchymal transition Source:UniProtKB1 Publication
Biological Process female gonad development Source:Ensembl
Biological Process female sex determination Source:UniProtKB1 Publication
Biological Process fibroblast growth factor receptor signaling pathway Source:Ensembl
Biological Process hormone metabolic process Source:Ensembl
Biological Process immature T cell proliferation in thymus Source:Ensembl
Biological Process kidney development Source:UniProtKB1 Publication
Biological Process liver development Source:UniProtKB1 Publication
Biological Process male gonad development Source:UniProtKB1 Publication
Biological Process mammary gland epithelium development Source:UniProtKB1 Publication
Biological Process meiotic nuclear division Source:Ensembl
Biological Process mesenchymal to epithelial transition Source:Ensembl
Biological Process metanephric mesenchymal cell differentiation Source:UniProtKB1 Publication
Biological Process metanephric nephron morphogenesis Source:Ensembl
Biological Process metanephric tubule formation Source:Ensembl
Biological Process negative regulation of androgen biosynthetic process Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic signaling pathway Source:Ensembl
Biological Process negative regulation of cell differentiation Source:Ensembl
Biological Process negative regulation of cell migration Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of fibroblast growth factor receptor signaling pathway Source:Ensembl
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of male gonad development Source:UniProtKB1 Publication
Biological Process negative regulation of steroid biosynthetic process Source:UniProtKB2 Publications
Biological Process negative regulation of testicular blood vessel morphogenesis Source:UniProtKB1 Publication
Biological Process negative regulation of testosterone biosynthetic process Source:UniProtKB1 Publication
Biological Process negative regulation of wound healing Source:Ensembl
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process non-canonical Wnt signaling pathway via MAPK cascade Source:BHF-UCL1 Publication
Biological Process oocyte development Source:Ensembl
Biological Process paramesonephric duct development Source:UniProtKB1 Publication
Biological Process pericyte cell differentiation Source:Ensembl
Biological Process positive regulation of aldosterone biosynthetic process Source:UniProtKB1 Publication
Biological Process positive regulation of bone mineralization Source:BHF-UCL1 Publication
Biological Process positive regulation of collagen biosynthetic process Source:BHF-UCL1 Publication
Biological Process positive regulation of cortisol biosynthetic process Source:UniProtKB1 Publication
Biological Process positive regulation of dermatome development Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB3 Publications
Biological Process positive regulation of focal adhesion assembly Source:Ensembl
Biological Process positive regulation of GTPase activity Source:Ensembl
Biological Process positive regulation of meiotic nuclear division Source:Ensembl
Biological Process positive regulation of osteoblast differentiation Source:BHF-UCL1 Publication
Biological Process positive regulation of stress fiber assembly Source:Ensembl
Biological Process regulation of cell-cell adhesion Source:Ensembl
Biological Process renal vesicle formation Source:Ensembl
Biological Process renal vesicle induction Source:Ensembl
Biological Process Sertoli cell differentiation Source:Ensembl
Biological Process smooth muscle cell differentiation Source:Ensembl
Biological Process somatotropin secreting cell differentiation Source:Ensembl
Biological Process tertiary branching involved in mammary gland duct morphogenesis Source:Ensembl
Biological Process thyroid-stimulating hormone-secreting cell differentiation Source:Ensembl

Secreted, extracellular space, extracellular matrix

46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL):
A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs.
Mullerian aplasia and hyperandrogenism (MULLAPL):
A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism.

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.