Mouse Anti-WWP1 Recombinant Antibody (1A7) (CBMAB-W0028-WJ)

Name: Mouse Anti-WWP1 Recombinant Antibody (1A7)
SKU: CBMAB-W0028-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1A7

Application

ELISA, IHC-P, WB, IF, IP

Immunogen

WWP1 (NP_008944, aa152-261 partial recombinant protein.

Specificity

Human

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WW domain containing E3 ubiquitin protein ligase 1

Introduction

WWP1 is a protein-coding gene. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. Diseases associated with WWP1 include Spastic Paraplegia 20, Autosomal Recessive. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is WWP2.

Entrez Gene ID

11059

UniProt ID

Q9H0M0

Alternative Names

AIP5; Tiul1; hSDRP1

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Biological Process

Biological Process central nervous system development Source:UniProtKB1 Publication
Biological Process ion transmembrane transport Source:Reactome
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process viral entry into host cell Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cell membrane
Nucleus

PTM

Auto-ubiquitinated and ubiquitinated by RNF11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-WWP1 Recombinant Antibody (CBWJW-084) (CAT#: CBMAB-W0235-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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