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Mouse Anti-WWP1 Recombinant Antibody (1A7) (CBMAB-W0028-WJ)

This product is a mouse antibody that recognizes WWP1. The antibody 1A7 can be used for immunoassay techniques such as: ELISA, IHC-P, WB, IF, IP.
See all WWP1 antibodies
Published Data
Fig.1 Lysates from DU145 cells transfected with hemagglutinin (HA)–PTEN were immunoprecipitated (IP) with an anti-PTEN antibody followed by mass spectrometric peptide sequencing.
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Fig.2 WWP1 interacts with PTEN endogenously. DU145 cells were immunoprecipitated with either anti-WWP1 or anti-PTEN antibody and then analyzed by Western blot (WB).
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Fig.3 Hematoxylin and eosin (H&E) and IHC staining of DLPs from Hi-Myc; Wwp1+/+ or Hi-Myc.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A7
Antibody Isotype
IgG2a, к
Application
ELISA, IHC-P, WB, IF, IP

Basic Information

Immunogen
WWP1 (NP_008944, aa152-261 partial recombinant protein.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WW domain containing E3 ubiquitin protein ligase 1
Introduction
WWP1 is a protein-coding gene. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. Diseases associated with WWP1 include Spastic Paraplegia 20, Autosomal Recessive. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is WWP2.
Entrez Gene ID
11059
UniProt ID
Q9H0M0
Alternative Names
AIP5; Tiul1; hSDRP1
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
Biological Process
Biological Process central nervous system development Source:UniProtKB1 Publication
Biological Process ion transmembrane transport Source:Reactome
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process viral entry into host cell Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cell membrane
Nucleus
PTM
Auto-ubiquitinated and ubiquitinated by RNF11.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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