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Mouse Anti-XPO4 Recombinant Antibody (183B1) (CBMAB-X0163-YC)

Provided herein is a Mouse monoclonal antibody against Human XPO4. The antibody, clone 183B1, can be used for immunoassay techniques, such as WB.
See all XPO4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Mouse, Rat
Clone
183B1
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant protein of human exportin 4 (aa 927-1151)
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in the amino acids 927-1151

Target

Full Name
Exportin 4
Introduction
XPO4 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments. XPO4 mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus, XPO4 binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.
Entrez Gene ID
Human64328
Mouse57258
Rat290280
Monkey703548
UniProt ID
HumanQ9C0E2
MouseQ9ESJ0
RatD3ZQI6
MonkeyF7A687
Alternative Names
exp4
Function
Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900).
In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645).
Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645).
XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645).
The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645).
Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119).
Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900).
Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity).
Biological Process
Biological Process positive regulation of protein export from nucleus Source:BHF-UCL1 Publication
Biological Process protein export from nucleus Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Shuttles between the nucleus and the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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