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Mouse Anti-XPOT Recombinant Antibody (CBYCX-124) (CBMAB-X0165-YC)

Provided herein is a Mouse monoclonal antibody against Human XPOT. The antibody, clone CBYCX-124, can be used for immunoassay techniques, such as WB.
See all XPOT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCX-124
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant human Exportin T
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Exportin For Trna
Introduction
XPOT belongs to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. XPOT mediates the nuclear export of aminoacylated tRNAs. In the nucleus, XPOT binds to tRNA and to the GTPase Ran in its active GTP-bound form.
Entrez Gene ID
11260
UniProt ID
O43592
Alternative Names
XPO3
Function
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Biological Process
Biological Process intracellular protein transport Source:InterPro
Biological Process tRNA export from nucleus Source:UniProtKB1 Publication
Biological Process tRNA re-export from nucleus Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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