Mouse Anti-XPOT Recombinant Antibody (CBYCX-124) (CBMAB-X0165-YC)

Name: Mouse Anti-XPOT Recombinant Antibody (CBYCX-124)
SKU: CBMAB-X0165-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYCX-124

Application

Immunogen

Recombinant human Exportin T

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Exportin For Trna

Introduction

XPOT belongs to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. XPOT mediates the nuclear export of aminoacylated tRNAs. In the nucleus, XPOT binds to tRNA and to the GTPase Ran in its active GTP-bound form.

Entrez Gene ID

11260

UniProt ID

O43592

Alternative Names

XPO3

Function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Biological Process

Biological Process intracellular protein transport Source:InterPro
Biological Process tRNA export from nucleus Source:UniProtKB1 Publication
Biological Process tRNA re-export from nucleus Source:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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