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Mouse Anti-XPOT Recombinant Antibody (CBFYE-1693) (CBMAB-E2368-FY)

This product is mouse antibody that recognizes XPOT. The antibody CBFYE-1693 can be used for immunoassay techniques such as: WB, IF.
See all XPOT antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle, Human
Clone
CBFYE-1693
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Mouse, Rat, Cattle, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.9 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Exportin For Trna
Introduction
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.
Entrez Gene ID
Human11260
Mouse73192
Rat314879
Cattle535264
UniProt ID
HumanO43592
MouseQ9CRT8
RatD3ZZ62
CattleE1B8Q8
Alternative Names
XPO3
Function
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Biological Process
Biological Process intracellular protein transport Source:InterPro
Biological Process tRNA export from nucleus Source:UniProtKB1 Publication
Biological Process tRNA re-export from nucleus Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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