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Mouse Anti-XPR1 Recombinant Antibody (CBYCX-125) (CBMAB-X0166-YC)

Provided herein is a Mouse monoclonal antibody against Human XPR1. The antibody, clone CBYCX-125, can be used for immunoassay techniques, such as WB.
See all XPR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCX-125
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
xenotropic and polytropic retrovirus receptor
Introduction
XPR1 is a receptor for the xenotropic and polytropic classes of murine leukemia viruses, which is involved in phosphate homeostasis by mediating phosphate export from the cell. XPR1 binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7). Defects in XPR1 have been associated with idiopathic basal ganglia calcification-6.
Entrez Gene ID
9213
UniProt ID
Q9UBH
Alternative Names
X3; SYG1; IBGC6; SLC53A1
Function
Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945).
Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106).
Biological Process
Biological Process cellular phosphate ion homeostasis Source:UniProtKB1 Publication
Biological Process cellular response to phosphate starvation Source:GO_Central1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process phosphate ion transmembrane transport Source:UniProtKB1 Publication
Biological Process phosphate ion transport Source:GO_Central1 Publication
Biological Process response to virus Source:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Basal ganglia calcification, idiopathic, 6 (IBGC6):
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
Topology
Cytoplasmic: 1-236
Helical: 237-257
Extracellular: 258-264
Helical: 258-264
Cytoplasmic: 286-318
Helical: 319-339
Extracellular: 340-345
Helical: 346-368
Cytoplasmic: 369-376
Helical: 377-397
Extracellular: 398-402
Helical: 403-423
Cytoplasmic: 424-473
Helical: 474-496
Extracellular: 497-507
Helical: 508-528
Cytoplasmic: 529-696
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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