Mouse Anti-XRCC1 Recombinant Antibody (2E8) (CBMAB-X0175-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, PubMed:34811483, PubMed:28002403).
Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483).
Biological Process cerebellum morphogenesis Source:Ensembl
Biological Process double-strand break repair via nonhomologous end joining Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process negative regulation of protection from non-homologous end joining at telomere Source:Ensembl
Biological Process negative regulation of protein ADP-ribosylation Source:UniProtKB2 Publications
Biological Process positive regulation of DNA ligase activity Source:UniProtKB1 Publication
Biological Process positive regulation of single strand break repair Source:UniProtKB1 Publication
Biological Process replication-born double-strand break repair via sister chromatid exchange Source:UniProtKB1 Publication
Biological Process response to hydroperoxide Source:UniProtKB1 Publication
Biological Process response to hypoxia Source:Ensembl
Biological Process response to organic substance Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process single strand break repair Source:InterPro
Biological Process telomeric DNA-containing double minutes formation Source:Ensembl
Biological Process voluntary musculoskeletal movement Source:UniProtKB1 Publication
Chromosome
Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403).
Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814).
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia.
Sumoylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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