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Recombinant Mouse Anti-XRCC2 Recombinant Antibody (1G4/1) (CBMAB-XB1237-YC)

Provided herein is a Mouse Recombinant Antibody against X-Ray Repair Cross Complementing 2. The antibody can be used for immunoassay techniques, such as WB.
See all XRCC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Hamster
Clone
1G4/1
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human, Hamster
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
X-ray repair complementing defective repair in Chinese hamster cells 2
Introduction
XRCC2 is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
Entrez Gene ID
Human7516
Hamster100750706
UniProt ID
HumanO43543
HamsterA0A3Q0DE59
Alternative Names
X-Ray Repair Cross Complementing 2; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2;X-Ray Repair Cross-Complementing Protein 2; DNA Repair Protein XRCC2
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Biological Process
Biological Process centrosome cycle Source:UniProtKB1 Publication
Biological Process DNA repair Source:BHF-UCL1 Publication
Biological Process double-strand break repair via homologous recombination Source:UniProtKB1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process meiotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic cell cycle Source:UniProtKB1 Publication
Biological Process multicellular organism growth Source:Ensembl
Biological Process negative regulation of neuron apoptotic process Source:Ensembl
Biological Process neurogenesis Source:Ensembl
Biological Process positive regulation of neurogenesis Source:Ensembl
Biological Process regulation of fibroblast apoptotic process Source:Ensembl
Biological Process response to gamma radiation Source:Ensembl
Biological Process response to X-ray Source:Ensembl
Biological Process somitogenesis Source:Ensembl
Biological Process strand invasion Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Involvement in disease
Fanconi anemia, complementation group U (FANCU):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Spermatogenic failure 50 (SPGF50):
An autosomal recessive infertility disorder characterized by azoospermia due to meiotic arrest at the zygotene stage of prophase I.
Premature ovarian failure 17 (POF17):
A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF17 transmission pattern is consistent with autosomal recessive inheritance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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