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Mouse Anti-XRN1 Recombinant Antibody (16C234) (CBMAB-X0249-YC)

Provided herein is a Mouse monoclonal antibody against Human XRN1. The antibody, clone 16C234, can be used for immunoassay techniques, such as ELISA, WB.
See all XRN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
16C234
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa 1455-1706 from human XRN1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5'-3' exoribonuclease 1
Introduction
XRN1 is a member of the 5'-3' exonuclease family. XRN1 plays a role in replication-dependent histone mRNA degradation and may act as a tumor suppressor protein in osteogenic sarcoma (OGS). Mutations in XRN1 are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation.
Entrez Gene ID
54464
UniProt ID
Q8IZH2
Alternative Names
SEP1
Function
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity).
Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Biological Process
Biological Process cellular response to cycloheximide Source:Ensembl
Biological Process cellular response to puromycin Source:Ensembl
Biological Process histone mRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of telomere maintenance via telomerase Source:BHF-UCL1 Publication
Biological Process negative regulation of translation Source:Ensembl
Biological Process nuclear mRNA surveillance Source:UniProtKB1 Publication
Biological Process nuclear-transcribed mRNA catabolic process Source:UniProtKB1 Publication
Biological Process response to testosterone Source:Ensembl
Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:BHF-UCL
Biological Process rRNA catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Discrete foci at the inner surface of the cell membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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