Mouse Anti-XRN1 Recombinant Antibody (16C234) (CBMAB-X0249-YC)

Name: Mouse Anti-XRN1 Recombinant Antibody (16C234)
SKU: CBMAB-X0249-YC
Rating: 5 (1 reviews)

See all XRN1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

16C234

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa 1455-1706 from human XRN1

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

5'-3' exoribonuclease 1

Introduction

XRN1 is a member of the 5'-3' exonuclease family. XRN1 plays a role in replication-dependent histone mRNA degradation and may act as a tumor suppressor protein in osteogenic sarcoma (OGS). Mutations in XRN1 are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation.

Entrez Gene ID

54464

UniProt ID

Q8IZH2

Alternative Names

SEP1

Function

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity).
Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

Biological Process

Biological Process cellular response to cycloheximide Source:Ensembl
Biological Process cellular response to puromycin Source:Ensembl
Biological Process histone mRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of telomere maintenance via telomerase Source:BHF-UCL1 Publication
Biological Process negative regulation of translation Source:Ensembl
Biological Process nuclear mRNA surveillance Source:UniProtKB1 Publication
Biological Process nuclear-transcribed mRNA catabolic process Source:UniProtKB1 Publication
Biological Process response to testosterone Source:Ensembl
Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:BHF-UCL
Biological Process rRNA catabolic process Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Discrete foci at the inner surface of the cell membrane.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-XRN1 Recombinant Antibody (16C234)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-XRN1 Recombinant Antibody (CBYCX-142) (CAT#: CBMAB-X0248-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry