Sign in or Register   Sign in or Register
  |  

XRN1

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.
Full Name
5'-3' exoribonuclease 1
Function
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity).
Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Biological Process
Biological Process cellular response to cycloheximide Source:Ensembl
Biological Process cellular response to puromycin Source:Ensembl
Biological Process histone mRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of telomere maintenance via telomerase Source:BHF-UCL1 Publication
Biological Process negative regulation of translation Source:Ensembl
Biological Process nuclear mRNA surveillance Source:UniProtKB1 Publication
Biological Process nuclear-transcribed mRNA catabolic process Source:UniProtKB1 Publication
Biological Process response to testosterone Source:Ensembl
Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:BHF-UCL
Biological Process rRNA catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Discrete foci at the inner surface of the cell membrane.

Anti-XRN1 antibodies

Loading...
Target: XRN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCX-142
Application*: WB
Target: XRN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16C234
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare