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Mouse Anti-YME1L1 Recombinant Antibody (2G10) (CBMAB-Y0075-LY)

This product is antibody recognizes YME1L1. The antibody 2G10 immunoassay techniques such as: WB.
See all YME1L1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G10
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 26-345 of human YME1L1
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
YME1-like 1 (S. cerevisiae)
Entrez Gene ID
UniProt ID
Function
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171).
Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975).
Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461).
Required for normal, constitutive degradation of PRELID1 (PubMed:27495975).
Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599).
Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).
Biological Process
Biological Process cell population proliferation Source:UniProtKB1 Publication
Biological Process mitochondrial protein catabolic process Source:UniProtKB2 Publications
Biological Process mitochondrial protein processing Source:UniProtKB1 Publication
Biological Process mitochondrion organization Source:UniProtKB2 Publications
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein hexamerization Source:UniProtKB1 Publication
Biological Process protein quality control for misfolded or incompletely synthesized proteins Source:UniProtKB1 Publication
Biological Process proteolysis Source:GO_Central1 Publication
Cellular Location
Mitochondrion inner membrane
Mitochondrion
Involvement in disease
Optic atrophy 11 (OPA11):
An autosomal recessive disease characterized by progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA11 patients also manifest delayed psychomotor development, intellectual disability, ataxia, and leukoencephalopathy on brain imaging.
Topology
Mitochondrial matrix: 1-295
Helical: 296-316
Mitochondrial intermembrane: 317-773
PTM
Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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