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Mouse Anti-ZBTB4 Recombinant Antibody (CBWJZ-045) (CBMAB-Z0097-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-045
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zinc finger and BTB domain containing 4
Introduction
ZBTB4 (Zinc Finger And BTB Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is ZBTB38.
Entrez Gene ID
57659
UniProt ID
Q9P1Z0
Alternative Names
ZNF903; KAISO-L1
Function
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).
Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Localizes to chromocenters.
PTM
Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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