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Mouse Anti-ZEB1 Recombinant Antibody (7E12) (CBMAB-Z0152-WJ)

This product is a mouse antibody that recognizes ZEB1. The antibody 7E12 can be used for immunoassay techniques such as: IHC-P, WB.
See all ZEB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7E12
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
Zinc Finger E-Box Binding Homeobox 1
Introduction
ZEB1 (Zinc Finger E-Box Binding Homeobox 1) is a Protein Coding gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Diseases associated with ZEB1 include Corneal Dystrophy, Fuchs Endothelial, 6 and Corneal Dystrophy, Posterior Polymorphous, 3. Among its related pathways are PAK Pathway and Cytokine Signaling in Immune system.
Entrez Gene ID
UniProt ID
Alternative Names
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
Function
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Biological Process
Biological Process anatomical structure development Source:GO_Central1 Publication
Biological Process cartilage development Source:Ensembl
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process cellular response to amino acid stimulus Source:Ensembl
Biological Process cellular response to transforming growth factor beta stimulus Source:Ensembl
Biological Process cochlea morphogenesis Source:Ensembl
Biological Process embryonic camera-type eye morphogenesis Source:Ensembl
Biological Process embryonic skeletal system morphogenesis Source:Ensembl
Biological Process forebrain development Source:Ensembl
Biological Process keratinocyte proliferation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of endothelial cell differentiation Source:BHF-UCL1 Publication
Biological Process negative regulation of keratinocyte proliferation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL2 Publications
Biological Process pattern specification process Source:Ensembl
Biological Process positive regulation of neuron differentiation Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process regulation of mesenchymal cell proliferation Source:Ensembl
Biological Process regulation of smooth muscle cell differentiation Source:Ensembl
Biological Process regulation of T cell differentiation in thymus Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of transforming growth factor beta receptor signaling pathway Source:Ensembl
Biological Process response to activity Source:Ensembl
Biological Process response to nutrient levels Source:Ensembl
Biological Process semicircular canal morphogenesis Source:Ensembl
Cellular Location
Nucleus
Involvement in disease
Corneal dystrophy, posterior polymorphous, 3 (PPCD3):
A subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
Corneal dystrophy, Fuchs endothelial, 6 (FECD6):
A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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