Mouse Anti-ZEB2 Recombinant Antibody (CBWJZ-111) (CBMAB-Z0167-WJ)

Name: Mouse Anti-ZEB2 Recombinant Antibody (CBWJZ-111)
SKU: CBMAB-Z0167-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBWJZ-111

Application

ELISA, WB, IF

Immunogen

ZFHX1B (AA1115-1214) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

ZEB2

Introduction

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene. Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

Entrez Gene ID

9839

UniProt ID

O60315

Alternative Names

KIAA0569; SIP-1; SIP1; ZFHX1B

Function

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212).
Represses transcription of E-cadherin (PubMed:16061479).
Represses expression of MEOX2 (PubMed:20516212).

Biological Process

Biological Process anatomical structure development Source:GO_Central1 Publication
Biological Process developmental pigmentation Source:BHF-UCLBy Similarity
Biological Process melanocyte migration Source:BHF-UCLBy Similarity
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL2 Publications
Biological Process nervous system development Source:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:DIBU1 Publication
Biological Process positive regulation of melanin biosynthetic process Source:BHF-UCL1 Publication
Biological Process positive regulation of melanocyte differentiation Source:BHF-UCLBy Similarity
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathway Source:DIBU1 Publication
Biological Process regulation of melanosome organization Source:BHF-UCLBy Similarity
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Nucleus
Chromosome

Involvement in disease

Mowat-Wilson syndrome (MOWS):
A complex developmental disorder characterized by intellectual disability, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Some patients manifest Hirschsprung disease.

PTM

Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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