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Mouse Anti-ZER1 Recombinant Antibody (CBWJZ-308) (CBMAB-Z0804-WJ)

This product is a mouse antibody that recognizes ZER1. The antibody CBWJZ-308 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ZER1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-308
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zyg-11 related, cell cycle regulator
Introduction
ZER1 (Zyg-11 Related Cell Cycle Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZYG11B.
Entrez Gene ID
10444
UniProt ID
Q7Z7L7
Alternative Names
ZYG; C9orf60; ZYG11BL
Function
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098).
Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214).
Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein quality control for misfolded or incompletely synthesized proteins Source:UniProtKB1 Publication
Cellular Location
Cul2-RING ubiquitin ligase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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