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Mouse Anti-ZFP57 Recombinant Antibody (CBWJZ-079) (CBMAB-Z0234-WJ)

This product is a mouse antibody that recognizes ZFP57. The antibody CBWJZ-079 can be used for immunoassay techniques such as: WB.
See all ZFP57 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-079
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human ZFP57.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
ZFP57 Zinc Finger Protein
Introduction
ZFP57 (ZFP57 Zinc Finger Protein) is a Protein Coding gene encodes the protein which is a zinc finger protein containing a KRAB domain.. Diseases associated with ZFP57 include Diabetes Mellitus, Transient Neonatal, 1 and Diabetes Mellitus, 6Q24-Related Transient Neonatal. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
Entrez Gene ID
346171
UniProt ID
Q9NU63
Alternative Names
ZFP57 Zinc Finger Protein; Zinc Finger Protein 698; C6orf40; Zfp-57; ZNF698
Function
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440).
Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440).
Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of gene expression by genomic imprinting Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Binds various differentially methylated regions (DMR).
Involvement in disease
Diabetes mellitus, transient neonatal, 1 (TNDM1):
An autosomal dominant form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first month of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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