Mouse Anti-ZMYND10 Recombinant Antibody (3A6) (CBMAB-Z0318-WJ)

Name: Mouse Anti-ZMYND10 Recombinant Antibody (3A6)
SKU: CBMAB-Z0318-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3A6

Application

ELISA, WB

Immunogen

ZMYND10 (AA1-440) full-length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

zinc finger, MYND-type containing 10

Introduction

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

51364

UniProt ID

O75800

Alternative Names

BLU; FLU; CILD22; DNAAF7

Function

Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471).
Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity).
May act by indirectly regulating transcription of dynein proteins (By similarity).

Biological Process

Biological Process cilium movement Source:Ensembl
Biological Process inner dynein arm assembly Source:UniProtKB2 Publications
Biological Process motile cilium assembly Source:UniProtKB2 Publications
Biological Process outer dynein arm assembly Source:UniProtKB2 Publications
Biological Process positive regulation of motile cilium assembly Source:UniProtKB
Biological Process protein localization to cilium Source:Ensembl

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Apical cell membrane
Dynein axonemal particle

Involvement in disease

Ciliary dyskinesia, primary, 22 (CILD22):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ZMYND10 Recombinant Antibody (3D11) (CAT#: CBMAB-Z0319-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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