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Mouse Anti-ZMYND10 Recombinant Antibody (3A6) (CBMAB-Z0318-WJ)

This product is a mouse antibody that recognizes ZMYND10. The antibody 3A6 can be used for immunoassay techniques such as: ELISA, WB.
See all ZMYND10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A6
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
ZMYND10 (AA1-440) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc finger, MYND-type containing 10
Introduction
This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
51364
UniProt ID
O75800
Alternative Names
BLU; FLU; CILD22; DNAAF7
Function
Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471).
Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity).
May act by indirectly regulating transcription of dynein proteins (By similarity).
Biological Process
Biological Process cilium movement Source:Ensembl
Biological Process inner dynein arm assembly Source:UniProtKB2 Publications
Biological Process motile cilium assembly Source:UniProtKB2 Publications
Biological Process outer dynein arm assembly Source:UniProtKB2 Publications
Biological Process positive regulation of motile cilium assembly Source:UniProtKB
Biological Process protein localization to cilium Source:Ensembl
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Apical cell membrane
Dynein axonemal particle
Involvement in disease
Ciliary dyskinesia, primary, 22 (CILD22):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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