Mouse Anti-ZNF148 Recombinant Antibody (CBWJZ-035) (CBMAB-Z0072-WJ)

Name: Mouse Anti-ZNF148 Recombinant Antibody (CBWJZ-035)
SKU: CBMAB-Z0072-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBWJZ-035

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

zinc finger protein 148

Introduction

ZNF148 (Zinc Finger Protein 148) is a Protein Coding gene encoded a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Diseases associated with ZNF148 include Global Developmental Delay, Absent Or Hypoplastic Corpus Callosum, And Dysmorphic Facies and Split-Hand/Foot Malformation 1. An important paralog of this gene is ZNF281.

Entrez Gene ID

Human	7707
Mouse	22661
Rat	58820

UniProt ID

Human	Q9UQR1
Mouse	Q61624
Rat	Q62806

Alternative Names

BERF-1; BFCOL1; GDACCF; ZBP-89; ZFP148; pHZ-52; HT-BETA

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

Biological Process

Biological Process cellular defense response Source:ProtInc1 Publication
Biological Process gamete generation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process protein-containing complex assembly Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication

Cellular Location

Nucleus

Involvement in disease

Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies (GDACCF):
An autosomal dominant syndrome characterized by underdevelopment of the corpus callosum, mild to moderate developmental delay and intellectual disability, variable microcephaly or mild macrocephaly, short stature, feeding problems, facial dysmorphisms, and cardiac and renal malformations.

PTM

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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