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Mouse Anti-ZNF148 Recombinant Antibody (CBWJZ-035) (CBMAB-Z0072-WJ)

This product is a mouse antibody that recognizes ZNF148. The antibody CBWJZ-035 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ZNF148 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJZ-035
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zinc finger protein 148
Introduction
ZNF148 (Zinc Finger Protein 148) is a Protein Coding gene encoded a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Diseases associated with ZNF148 include Global Developmental Delay, Absent Or Hypoplastic Corpus Callosum, And Dysmorphic Facies and Split-Hand/Foot Malformation 1. An important paralog of this gene is ZNF281.
Entrez Gene ID
Human7707
Mouse22661
Rat58820
UniProt ID
HumanQ9UQR1
MouseQ61624
RatQ62806
Alternative Names
BERF-1; BFCOL1; GDACCF; ZBP-89; ZFP148; pHZ-52; HT-BETA
Function
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Biological Process
Biological Process cellular defense response Source:ProtInc1 Publication
Biological Process gamete generation Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process protein-containing complex assembly Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies (GDACCF):
An autosomal dominant syndrome characterized by underdevelopment of the corpus callosum, mild to moderate developmental delay and intellectual disability, variable microcephaly or mild macrocephaly, short stature, feeding problems, facial dysmorphisms, and cardiac and renal malformations.
PTM
Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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