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Mouse Anti-ZNF274 Recombinant Antibody (3C10) (CBMAB-A10154-LY)

The product is antibody recognizes ZNF274. The antibody 3C10 immunoassay techniques such as: WB, ELISA.
See all ZNF274 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ZNF274 (NP_598009, 420 a.a. ~ 530 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 274
Introduction
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq]
Entrez Gene ID
10782
UniProt ID
Q96GC6
Alternative Names
DKFZp686K08243; FLJ37843; HFB101; ZF2; ZKSCAN19
Function
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription Source:ProtInc1 Publication
Biological Process regulation of histone H3-K9 trimethylation Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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