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Mouse Anti-ZNF341 Recombinant Antibody (3B10) (CBMAB-0847-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B10
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Protein Domain
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger family member 341
Introduction
ZNF341 may be involved in transcriptional regulation.
Entrez Gene ID
84905
UniProt ID
Q9BYN7
Alternative Names
dJ553F4.3
Function
Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.
Biological Process
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Hyper-IgE recurrent infection syndrome 3, autosomal recessive (HIES3):
An immunologic disorder characterized by skin bacterial infections in particular with Staphylococcus aureus, susceptibility to fungal infections such as chronic mucocutaneous candidiasis, atopic dermatitis, recurrent respiratory infections, bronchiectasis, and increased serum IgE and IgG. Immunologic work-up shows impaired differentiation of CD4+ T cells into T-helper 17 cells, decreased memory B cells, and often decreased NK cells. Some patients manifest extrahemapoietic features, including facial dysmorphism, abnormal dentition, alopecia, joint hypermobility and bone fractures. Disease onset is in early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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