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Mouse Anti-ZNRF1 Recombinant Antibody (1H4) (CBMAB-Z0695-WJ)

This product is a mouse antibody that recognizes ZNRF1. The antibody 1H4 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all ZNRF1 antibodies
Published Data
Fig.1 Effect of Ser19Ala mutation on the reversible membrane-to-cytosol translocation of ZNRF2.
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Fig.2 ZNRF2 knockdown rescues ouabain-induced decrease of total and plasma membrane levels of Na+/K+ ATPase α1.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
ZNRF1 (AA74-178) partial recombinant protein with GST tag. Immunogen sequence: PASRGTGDSE RAPGGGGSAS DSTYAHGNGY QETGGGHHRD GMLYLGSRAS LADALPLHIA PRWFSSHSGF KCPICSKSVA SDEMEMHFIM CLSKPRLSYN DDVLT
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc and ring finger 1
Introduction
ZNRF1 (Zinc And Ring Finger 1) is a Protein Coding gene. Diseases associated with ZNRF1 include B-Cell Adult Acute Lymphocytic Leukemia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is ZNRF2.
Entrez Gene ID
84937
UniProt ID
Q8ND25
Alternative Names
NIN283
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process protein K48-linked ubiquitination Source:UniProtKB
Cellular Location
Endosome
Lysosome
Membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Note: Associated with synaptic vesicle membranes in neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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