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C3 Matched Antibody Pair (157) (APMAB-157LY)

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Datasheet
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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-C3 monoclonal, IgG antibody, 100 ug
Detection Antibody
Anti-C3 Biotinylated mouse monoclonal, IgG antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Alternative Names
ARMD9,ASP,CPAMD1
Entrez Gene ID
718
More Infomation

Yuan, K., Ye, J., Liu, Z., Ren, Y., He, W., Xu, J., ... & Yuan, Y. (2020). Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression. Journal of Experimental & Clinical Cancer Research, 39(1), 1-15.

Mastaglio, S., Ruggeri, A., Risitano, A. M., Angelillo, P., Yancopoulou, D., Mastellos, D. C., ... & Ciceri, F. (2020). The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clinical Immunology, 215, 108450.

Mastellos, D. C., da Silva, B. G. P., Fonseca, B. A., Fonseca, N. P., Auxiliadora-Martins, M., Mastaglio, S., ... & Lambris, J. D. (2020). Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy. Clinical Immunology, 220, 108598.

Liao, D. S., Grossi, F. V., El Mehdi, D., Gerber, M. R., Brown, D. M., Heier, J. S., ... & Francois, C. G. (2020). Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial. Ophthalmology, 127(2), 186-195.

Zhang, L. Y., Pan, J., Mamtilahun, M., Zhu, Y., Wang, L., Venkatesh, A., ... & Yang, G. Y. (2020). Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. Theranostics, 10(1), 74.

Wu, T., Dejanovic, B., Gandham, V. D., Gogineni, A., Edmonds, R., Schauer, S., ... & Hanson, J. E. (2019). Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy. Cell reports, 28(8), 2111-2123.

Bosco, A., Anderson, S. R., Breen, K. T., Romero, C. O., Steele, M. R., Chiodo, V. A., ... & Vetter, M. L. (2018). Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma. Molecular Therapy, 26(10), 2379-2396.

Sorbara, M. T., Foerster, E. G., Tsalikis, J., Abdel-Nour, M., Mangiapane, J., Sirluck-Schroeder, I., ... & Philpott, D. J. (2018). Complement C3 drives autophagy-dependent restriction of cyto-invasive bacteria. Cell host & microbe, 23(5), 644-652.

Shi, Q., Chowdhury, S., Ma, R., Le, K. X., Hong, S., Caldarone, B. J., ... & Lemere, C. A. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Science translational medicine, 9(392).

Mastellos, D. C., Reis, E. S., Ricklin, D., Smith, R. J., & Lambris, J. D. (2017). Complement C3-targeted therapy: replacing long-held assertions with evidence-based discovery. Trends in immunology, 38(6), 383-394.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant C3 protein, His Tag (CAT#: V2LY-0526-LY1475)

Human Recombinant C3 protein, His Tag (CAT#: V2LY-0526-LY3334)

Human Recombinant C3 protein, His Tag-1 (CAT#: V2LY-0526-LY3335)

Mouse Recombinant C3 protein, His Tag (CAT#: V2LY-0526-LY8147)

Mouse Recombinant C3 protein, His Tag-1 (CAT#: V2LY-0526-LY8148)

Related Products

Rabbit Anti-C3 Recombinant Antibody (ARC0541) (CAT#: CBMAB-1245-CN)

Rabbit Anti-C3 Recombinant Antibody (
8C3) (CAT#: V2LY-0725-LY1341)

Human Recombinant C3 protein, His Tag (CAT#: V2LY-0526-LY3334)

Mouse Anti-C3 Recombinant Antibody (1D20) (CAT#: CBMAB-C3821-LY)

Human Recombinant C3 protein, His Tag-1 (CAT#: V2LY-0526-LY3335)

Mouse Anti-C3 Recombinant Antibody (3B4) (CAT#: CBMAB-C7035-LY)

Rat Anti-C3 Recombinant Antibody (11H9) (CAT#: CBMAB-C0566-LY)

Mouse Anti-C3 Recombinant Antibody (CBT4606) (CAT#: V2LY-0625-LY550)

Mouse Anti-C3 Recombinant Antibody (CBCNC-133) (CAT#: CBMAB-C1154-CN)

Cynomolgus Recombinant C3 protein, His Tag (CAT#: V2LY-0526-LY1475)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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