Canine Recombinant FGF9 protein, Fc Tag (V2LY-0526-LY1245)

Name: Canine Recombinant FGF9 protein, Fc Tag
SKU: V2LY-0526-LY1245
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Canine

Tag

Fc Tag

Protein Construction

This product is Canine Recombinant FGF9 protein, Fc Tag consist of Amino Acid: 4-208 and predicts a molecular mass of 49.8 kDa.

Molecule Mass

49.8 kDa

Sequence

Amino Acid: 4-208

Species

Canine

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>75% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 9

Research Area

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Lung development Source: GO_Central
Male gonad development Source: UniProtKB
Negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of epithelial cell proliferation Source: GO_Central
Positive regulation of gene expression Source: GO_Central
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc
Substantia nigra development Source: UniProtKB

Cellular Location

Secreted

Involvement in disease

Multiple synostoses syndrome 3 (SYNS3):
A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.

PTM

Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
N-glycosylated.

Li, A., Tian, J., Yang, J., Ren, X., Zhou, Z., & Zhou, W. (2021). Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. Neuroreport, 32(4), 321-325.

Yusuf, I. O., Chen, H. M., Cheng, P. H., Chang, C. Y., Tsai, S. J., Chuang, J. I., ... & Yang, S. H. (2021). Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Molecular Neurobiology, 58(5), 2396-2406.

Zhang, X., Weng, M., & Chen, Z. (2021). Fibroblast Growth Factor 9 (FGF9) negatively regulates the early stage of chondrogenic differentiation. Plos One, 16(2), e0241281.

Huang, K., Wang, Y., Zhu, J., Xiong, Y., & Lin, Y. (2021). Regulation of fibroblast growth factor 9 on the differentiation of goat intramuscular adipocytes. Animal Science Journal, 92(1), e13627.

Rejali, L., Seyedna, S. Y., Aghdaei, H. A., Mojarad, E. N., & Hashemi, M. (2021). Fibroblast growth factor 9 correlation with lymphatic and vascular invasion in colorectal cancer. International Journal of Cancer Management, 14(2).

Gao, X., Zhu, M., An, S., Liang, Y., Yang, H., Pang, J., ... & Wang, F. (2020). Long non-coding RNA LOC105611671 modulates fibroblast growth factor 9 (FGF9) expression by targeting oar-miR-26a to promote testosterone biosynthesis in Hu sheep. Reproduction, Fertility and Development, 32(4), 373-382.

Seitz, T., Freese, K., Dietrich, P., Thasler, W. E., Bosserhoff, A., & Hellerbrand, C. (2020). Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma. Scientific reports, 10(1), 1-9.

Huang, J., Wang, K., Shiflett, L. A., Brotto, L., Bonewald, L. F., Wacker, M. J., ... & Brotto, M. (2019). Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells. Cell Cycle, 18(24), 3562-3580.

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., ... & Yang, S. H. (2018). Fibroblast growth factor 9 suppresses striatal cell death dominantly through ERK signaling in Huntington’s disease. Cellular Physiology and Biochemistry, 48(2), 605-617.

He, X., Chen, S. Y., Yang, Z., Zhang, J., Wang, W., Liu, M. Y., ... & Sun, G. G. (2018). miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2). Journal of Experimental & Clinical Cancer Research, 37(1), 1-16.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FGF9 protein, hFc Tag (CAT#: V2LY-0526-LY4064)

Human Recombinant FGF9 protein (CAT#: V2LY-0526-LY4065)

Mouse Fgf9 ELISA Kit (CAT#: V2LY-0626-LY1837)

Human FGF9 ELISA Kit (CAT#: V2LY-0626-LY4584)

Related Products

Mouse Anti-FGF9 Recombinant Antibody (CBXF-2626) (CAT#: V2LY-0925-LY1629)

Mouse Anti-FGF9 Recombinant Antibody (BA0187) (CAT#: V2LY-0925-LY1628)

Human Recombinant FGF9 protein (CAT#: V2LY-0526-LY4065)

Mouse Anti-FGF9 Recombinant Antibody (CBXF-2164) (CAT#: V2LY-0925-LY1630)

Mouse Anti-FGF9 Recombinant Antibody (F1705) (CAT#: V2LY-0925-LY1631)

Mouse Anti-FGF9 Recombinant Antibody (CBXF-1744) (CAT#: V2LY-0925-LY1633)

Human FGF9 ELISA Kit (CAT#: V2LY-0626-LY4584)

Mouse Anti-FGF9 Recombinant Antibody (CBXF-0590) (CAT#: V2LY-0925-LY1632)

Human Recombinant FGF9 protein, hFc Tag (CAT#: V2LY-0526-LY4064)

Mouse Fgf9 ELISA Kit (CAT#: V2LY-0626-LY1837)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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