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CBS Matched Antibody Pair (192) (APMAB-192LY)

This antibody pair set can be used for detecting and quantifying protein level of human CBS.
See all CBS antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CBS polyclonal antibody, 100 ug
Detection Antibody
Anti-CBS Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Alternative Names
Cystathionine-Beta-Synthase; Serine Sulfhydrase; Beta-Thionase; EC 4.2.1.22; Cystathionine Beta-Synthase; Methylcysteine Synthase; HIP4;
Entrez Gene ID
875
UniProt ID
P35520

Bublil, E. M., & Majtan, T. (2020). Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie, 173, 48-56.

Rao, G., Murphy, B., Dey, A., Dwivedi, S. K. D., Zhang, Y., Roy, R. V., ... & Mukherjee, P. (2020). Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells. The FASEB Journal, 34(7), 9372-9392.

Sun, S., Weile, J., Verby, M., Wu, Y., Wang, Y., Cote, A. G., ... & Roth, F. P. (2020). A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase. Genome medicine, 12(1), 1-18.

Zheng, F., Han, J., Lu, H., Cui, C., Yang, J., Cui, Q., ... & Geng, B. (2018). Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(10), 3281-3291.

Voskoboeva, E., Semyachkina, A., Yablonskaya, M., & Nikolaeva, E. (2018). Homocystinuria due to cystathionine beta-synthase (CBS) deficiency in Russia: Molecular and clinical characterization. Molecular genetics and metabolism reports, 14, 47-54.

Majtan, T., Krijt, J., Sokolová, J., Křížková, M., Ralat, M. A., Kent, J., ... & Kraus, J. P. (2018). Biogenesis of hydrogen sulfide and thioethers by cystathionine beta-synthase. Antioxidants & redox signaling, 28(4), 311-323.

Yin, W. L., Yin, W. G., Huang, B. S., & Wu, L. X. (2017). Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats. Neuroscience letters, 657, 45-52.

Majtan, T., Pey, A. L., Gimenez-Mascarell, P., Martínez-Cruz, L. A., Szabo, C., Kožich, V., & Kraus, J. P. (2017). Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. Targeting Trafficking in Drug Development, 345-383.

Hendrix, P., Foreman, P. M., Harrigan, M. R., Fisher, W. S., Vyas, N. A., Lipsky, R. H., ... & Griessenauer, C. J. (2017). Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage. Journal of neurosurgery, 128(6), 1771-1777.

Nandi, S. S., & Mishra, P. K. (2017). H 2 S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes. Scientific reports, 7(1), 1-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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