Cynomolgus Recombinant EPO protein, His Tag (V2LY-0526-LY1503)

Name: Cynomolgus Recombinant EPO protein, His Tag
SKU: V2LY-0526-LY1503
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His Tag

Protein Construction

This product is Cynomolgus Recombinant EPO protein, His Tag consist of Amino Acid: 1-192 and predicts a molecular mass of 19.7 kDa.

Molecule Mass

19.7 kDa

Sequence

Amino Acid: 1-192

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Erythropoietin

Research Area

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.

Biological Process

Acute-phase response Source: Ensembl
Aging Source: Ensembl
Apoptotic process Source: Ensembl
Blood circulation Source: ProtInc
Cellular hyperosmotic response Source: BHF-UCL
Embryo implantation Source: Ensembl
Erythrocyte differentiation Source: BHF-UCL
Erythrocyte maturation Source: UniProtKB-KW
Erythropoietin-mediated signaling pathway Source: UniProtKB
Hemoglobin biosynthetic process Source: Ensembl
Negative regulation of calcium ion transport into cytosol Source: BHF-UCL
Negative regulation of cation channel activity Source: BHF-UCL
Negative regulation of erythrocyte apoptotic process Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: BHF-UCL
Negative regulation of neuron death Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of activated T cell proliferation Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of Ras protein signal transduction Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Response to axon injury Source: Ensembl
Response to dexamethasone Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to estrogen Source: Ensembl
Response to hyperoxia Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to salt stress Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin A Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Microvascular complications of diabetes 2 (MVCD2):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Erythrocytosis, familial, 5 (ECYT5):
An autosomal dominant disorder characterized by elevated serum hemoglobin and hematocrit. Some patients have increased serum erythropoietin levels.
Diamond-Blackfan anemia-like (DBAL):
An autosomal recessive hematologic disease characterized by severe red cell hypoplastic anemia, selective absence of red cell precursors and progenitors seen on bone marrow biopsy, and increased serum erythropoietin.

Tsiftsoglou, A. S. (2021). Erythropoietin (EPO) as a key regulator of erythropoiesis, bone remodeling and endothelial transdifferentiation of multipotent mesenchymal stem cells (MSCs): implications in regenerative medicine. Cells, 10(8), 2140.

Larpthaveesarp, A., Pathipati, P., Ostrin, S., Rajah, A., Ferriero, D., & Gonzalez, F. F. (2021). Enhanced mesenchymal stromal cells or erythropoietin provide long-term functional benefit after neonatal stroke. Stroke, 52(1), 284-293.

Peng, B., Kong, G., Yang, C., & Ming, Y. (2020). Erythropoietin and its derivatives: from tissue protection to immune regulation. Cell death & disease, 11(2), 1-12.

Soliz, J., Schneider-Gasser, E. M., Arias-Reyes, C., Aliaga-Raduan, F., Poma-Machicao, L., Zubieta-Calleja, G., ... & Dutschmann, M. (2020). Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?. Respiratory physiology & neurobiology, 279, 103476.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant EPO protein, Fc Tag (CAT#: V2LY-0526-LY186)

Mouse Recombinant EPO protein (CAT#: V2LY-0526-LY8278)

Mouse Recombinant EPO protein, His Tag (CAT#: V2LY-0526-LY8279)

Rat Recombinant EPO protein, His Tag (CAT#: V2LY-0526-LY9370)

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Mouse Recombinant EPO protein, His Tag (CAT#: V2LY-0526-LY8279)

Rat Anti-EPO Recombinant Antibody (E1585) (CAT#: V2LY-0825-LY534)

Human Recombinant EPO protein, Fc Tag (CAT#: V2LY-0526-LY186)

Mouse Anti-EPO Recombinant Antibody (CBT496) (CAT#: V2LY-0625-LY3476)

Mouse Anti-EPO Recombinant Antibody (1B12) (CAT#: CBMAB-A2671-LY)

Rat Anti-EPO Recombinant Antibody (16) (CAT#: CBMAB-E1578-FY)

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Mouse Anti-EPO Recombinant Antibody (4F11) (CAT#: CBMAB-AO408LY)

Isotype control

For research use only. Not intended for any clinical use.

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