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DNAJB6 Matched Antibody Pair (348) (APMAB-348LY)

This antibody pair set can be used for detecting and quantifying protein level of human DNAJB6.
See all DNAJB6 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-DNAJB6 polyclonal antibody, 100 ug
Detection Antibody
Anti-DNAJB6 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member B6; DnaJ (Hsp40) Homolog, Subfamily B, Member 6; Heat Shock Protein J2; HSJ-2; HHDJ1; MSJ-1; HSJ2; MRJ; Limb Girdle Muscular Dystrophy 1D (Autosomal Dominant);
Entrez Gene ID
10049
UniProt ID
O75190

Österlund, N., Lundqvist, M., Ilag, L. L., Gräslund, A., & Emanuelsson, C. (2020). Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation. Journal of Biological Chemistry, 295(24), 8135-8144.

Palmio, J., Jonson, P. H., Inoue, M., Sarparanta, J., Bengoechea, R., Savarese, M., ... & Udd, B. (2020). Mutations in the J domain of DNAJB6 cause dominant distal myopathy. Neuromuscular Disorders, 30(1), 38-46.

Thiruvalluvan, A., de Mattos, E. P., Brunsting, J. F., Bakels, R., Serlidaki, D., Barazzuol, L., ... & Kampinga, H. H. (2020). DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis. Molecular cell, 78(2), 346-358.

Rodríguez-González, C., Lin, S., Arkan, S., & Hansen, C. (2020). Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Scientific reports, 10(1), 1-9.

Jiang, B., Zhao, Y., Shi, M. O., Song, L., Wang, Q., Qin, Q., ... & Liu, X. (2020). DNAJB6 promotes ferroptosis in esophageal squamous cell carcinoma. Digestive diseases and sciences, 65(7), 1999-2008.

Zhang, L., Zhou, Q., Qiu, Q., Hou, L., Wu, M., Li, J., ... & Lu, Y. (2019). CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Molecular cancer, 18(1), 1-19.

Månsson, C., Van Cruchten, R. T., Weininger, U., Yang, X., Cukalevski, R., Arosio, P., ... & Emanuelsson, C. (2018). Conserved S/T residues of the human chaperone DNAJB6 are required for effective inhibition of Aβ42 amyloid fibril formation. Biochemistry, 57(32), 4891-4902.

Jonson, P. H., Palmio, J., Johari, M., Penttilä, S., Evilä, A., Nelson, I., ... & Udd, B. (2018). Novel mutations in DNAJB6 cause LGMD 1D and distal myopathy in French families. European Journal of Neurology, 25(5), 790-794.

Aprile, F. A., Källstig, E., Limorenko, G., Vendruscolo, M., Ron, D., & Hansen, C. (2017). The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific reports, 7(1), 1-11.

Tsai, P. C., Tsai, Y. S., Soong, B. W., Huang, Y. H., Wu, H. T., Chen, Y. H., ... & Lee, Y. C. (2017). A novel DNAJB6 mutation causes dominantly inherited distal‐onset myopathy and compromises DNAJB6 function. Clinical Genetics, 92(2), 150-157.

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For research use only. Not intended for any clinical use.

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