EDN3 Matched Antibody Pair (364) (APMAB-364LY)

Name: EDN3 Matched Antibody Pair (364)
SKU: APMAB-364LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-EDN3 polyclonal antibody, 100 ug

Detection Antibody

Anti-EDN3 Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Alternative Names

Endothelin 3; Preproendothelin-3; PPET3; ET-3; Endothelin-3; HSCR4; WS4B; ET3;

Entrez Gene ID

1908

UniProt ID

P14138

More Infomation

References

Chen, H., Cai, B., Liu, K., & Hua, Q. (2021). miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells Corrigendum in/10.3892/mmr. 2021.12105. Molecular medicine reports, 23(4), 1-1.

Freitas, J. T., Lopez, J., Llorian, C., Boroni, M., & Kos, L. (2021). The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. Pigment Cell & Melanoma Research, 34(6), 1084-1093.

Lopez, J. R. (2019). Over-expression of endothelin-3 increases tumor volume in a transgenic murine melanoma model.

Darwish, H. Y., Zhang, Y., Cui, K., Yang, Z., Han, D., Dong, X., ... & Deng, X. (2018). Molecular cloning and characterization of the endothelin 3 gene in black bone sheep. Journal of animal science and biotechnology, 9(1), 1-11.

Bondurand, N., Dufour, S., & Pingault, V. (2018). News from the endothelin-3/EDNRB signaling pathway: role during enteric nervous system development and involvement in neural crest-associated disorders. Developmental biology, 444, S156-S169.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EDN3 (AA 1-239) Recombinant Antibody (CBFYE-0173)

Mouse Anti-EDN3 Recombinant Antibody (CBFYE-0444)

Mouse Anti-EDN3 Recombinant Antibody (CBFYE-0173)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Second antibody and isotype control

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