Anti-ERBB2 Antibody (PTM-CBMAB-0630LY) Immunohistochemistry Kit (V2LY-0826-LY178)

Name: Anti-ERBB2 Antibody (PTM-CBMAB-0630LY) Immunohistochemistry Kit
SKU: V2LY-0826-LY178
Rating: 5 (1 reviews)

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Summary

Product Overview

This comprehensive, all-in-one kit is designed for the precise immunohistochemical (IHC) detection of target protein in tissue samples. Unlike standard detection kits, it includes a highly specific rabbit primary antibody bundled directly with our robust Polymer HRP detection system. The kit provides every essential reagent needed for the entire IHC workflow-from the initial antigen retrieval buffer to the final mounting media. By offering a pre-matched primary antibody with optimized buffers and secondary detection reagents, this kit eliminates the need for tedious protocol optimization and reagent sourcing, ensuring consistent, high-quality staining results.

Primary Antibody Cat.

PTM-CBMAB-0630LY

Primary Antibody

Rat Anti-ESR1 Recombinant Antibody (10)

Secondary Antibody Host Species

Goat

Secondary Antibody Species Specificity

Rabbit

Application

IHC-P

Sample Type

FFPE tissue

Test Size

50 Tests

Storage

Stored at 2-8°C. The kit is stable for 6 months from the date of receipt.

Key Features

Target-Specific Primary Antibody

Includes a highly validated rabbit primary antibody, ensuring reliable and specific target localization.

Complete End-to-End Solution

Contains all 11 essential components required for a full IHC workflow, including Tris-EDTA Antigen Retrieval Buffer, Blocking Buffer, Polymer HRP-Goat anti-Rabbit Secondary Antibody, DAB Chromogens, Counterstain, and Mounting Media.

Streamlined Workflow

Pre-optimized reagents work seamlessly with the included primary antibody, saving researchers significant time on antibody titration and protocol adjustments.

Sample Compatibility

Highly recommended and optimized for Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

Kit Capacity

Provides sufficient reagents (50T) to perform 50 tests, depending on tissue section size.

More Infomation

Sub Cat	Reagents	Size
LV01	Antigen Retrieval Buffer (50× Tris-EDTA)	100 ml
LV02	Washing Buffer (30×)	120 ml
LV03	Blocking Buffer	5 ml
LV04	Quenching buffer (RTU)	5 ml
LV05	Primary Antibody Diluent (RTU)	100 ml
LV06R	HRP-Goat anti-Rabbit Secondary Antibody	5 ml
LV07	Chromogen Component A	0.2 ml
LV08	Chromogen Component B	4 ml
LV09	Signal Enhancer	5 ml
LV10	Counter Staining Reagent	5 ml
LV11	Mounting Media	5 ml

Tarantino, P., Jin, Q., Tayob, N., Jeselsohn, R. M., Schnitt, S. J., Vincuilla, J., ... & Tolaney, S. M. (2022). Prognostic and biologic significance of ERBB2-low expression in early-stage breast cancer. JAMA oncology, 8(8), 1177-1183.

Abuhelwa, Z., Alloghbi, A., Alqahtani, A., & Nagasaka, M. (2022). Trastuzumab deruxtecan-induced interstitial lung disease/pneumonitis in ERBB2-positive advanced solid malignancies: a systematic review. Drugs, 1-9.

Tarantino, P., Modi, S., Tolaney, S. M., Cortés, J., Hamilton, E. P., Kim, S. B., ... & Curigliano, G. (2021). Interstitial lung disease induced by anti-ERBB2 antibody-drug conjugates: a review. JAMA oncology, 7(12), 1873-1881.

Rugo, H. S., Im, S. A., Cardoso, F., Cortés, J., Curigliano, G., Musolino, A., ... & SOPHIA Study Group. (2021). Efficacy of margetuximab vs trastuzumab in patients with pretreated ERBB2-positive advanced breast cancer: a phase 3 randomized clinical trial. JAMA oncology, 7(4), 573-584.

Bychkov, D., Linder, N., Tiulpin, A., Kücükel, H., Lundin, M., Nordling, S., ... & Lundin, J. (2021). Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy. Scientific reports, 11(1), 1-10.

Aharonov, A., Shakked, A., Umansky, K. B., Savidor, A., Genzelinakh, A., Kain, D., ... & Tzahor, E. (2020). ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nature cell biology, 22(11), 1346-1356.

Zhang, J., Liu, S., Li, Q., Shi, Y., Wu, Y., Liu, F., ... & Liu, H. (2020). The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer. Cell Death & Differentiation, 27(9), 2710-2725.

Subramanian, J., Katta, A., Masood, A., Vudem, D. R., & Kancha, R. K. (2019). Emergence of ERBB2 mutation as a biomarker and an actionable target in solid cancers. The Oncologist, 24(12), e1303-e1314.

Sanchez-Vega, F., Hechtman, J. F., Castel, P., Ku, G. Y., Tuvy, Y., Won, H., ... & Janjigian, Y. Y. (2019). EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric CancerAfatinib in ERBB2-Amplified Gastric Cancer. Cancer discovery, 9(2), 199-209.

Honkoop, H., de Bakker, D. E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P. D., ... & Bakkers, J. (2019). Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. Elife, 8, e50163.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant ERBB2 protein, His Tag (CAT#: V2LY-0526-LY1259)

Cynomolgus Recombinant ERBB2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1531)

Cynomolgus Recombinant ERBB2 protein, His Tag (CAT#: V2LY-0526-LY1532)

Human Recombinant ERBB2 (A775_G776insYVMA, C805S), Active protein, GST Tag (CAT#: V2LY-0526-LY4484)

Human Recombinant ERBB2 (A775_G776insYVMA), Active protein, GST Tag (CAT#: V2LY-0526-LY4485)

Human Recombinant ERBB2 (A775_G776insYVMA), Active protein, GST Tag-1 (CAT#: V2LY-0526-LY4486)

Human Recombinant ERBB2 protein, GST Tag (CAT#: V2LY-0526-LY4487)

Human Recombinant ERBB2 protein, ECD, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY4488)

Human Recombinant ERBB2 protein, ECD, APC Conjugated, His Tag (CAT#: V2LY-0526-LY4489)

Human Recombinant ERBB2 (C805S), Active protein, GST Tag (CAT#: V2LY-0526-LY4490)

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Human Recombinant ERBB2 protein, ECD, PE Conjugated, His Tag (CAT#: V2LY-0526-LY4522)

Human Recombinant ERBB2 protein, GST Tag (CAT#: V2LY-0526-LY4487)

Anti-ERBB2 Antibody (CBMAB-CA015LY) Immunohistochemistry Kit (CAT#: V2LY-0826-LY183)

Human Recombinant ERBB2 (V956R), Active protein, His Tag (CAT#: V2LY-0526-LY4527)

Human Recombinant ERBB2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4502)

Human Recombinant ERBB2, Active protein, GST Tag (CAT#: V2LY-0526-LY4510)

Human Recombinant ERBB2 proteinECD, Biotin Conjugated, (CAT#: V2LY-0526-LY4496)

Rat Erbb2 ELISA Kit (CAT#: V2LY-0626-LY3052)

Rabbit Anti-ERBB2 Recombinant Antibody (
5F6) (CAT#: V2LY-0725-LY1129)

Mouse Erbb2 ELISA Kit (CAT#: V2LY-0626-LY3363)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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