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FRG1 Matched Antibody Pair (452) (APMAB-452LY)

This antibody pair set can be used for detecting and quantifying protein level of human FRG1.
See all FRG1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FRG1 monoclonal antibody, 100 ug
Detection Antibody
Anti-FRG1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. [provided by RefSeq, Jul 2008]
Alternative Names
FSHD Region Gene 1; FSHD Region Gene 1 Protein; Facioscapulohumeral Muscular Dystrophy Region Gene-1; Protein FRG1; FRG1A; FSG1;
Entrez Gene ID
2483
UniProt ID
Q14331

Palo, A., Patel, S. A., Sahoo, B., Chowdary, T. K., & Dixit, M. (2023). FRG1 is a direct transcriptional regulator of nonsense-mediated mRNA decay genes. Genomics, 115(1), 110539.

Mukherjee, B., Brahma, P., Mohapatra, T., Chawla, S., & Dixit, M. (2023). Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway. FEBS Open Bio.

Mukherjee, B., Tiwari, A., Palo, A., Pattnaik, N., Samantara, S., & Dixit, M. (2022). Reduced expression of FRG1 facilitates breast cancer progression via GM-CSF/MEK-ERK axis by abating FRG1 mediated transcriptional repression of GM-CSF. Cell Death Discovery, 8(1), 442.

Khan, R., Palo, A., & Dixit, M. (2021). Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model. Scientific Reports, 11(1), 22505.

Mukherjee, B., Tiwari, A., & Dixit, M. (2020). Novel tumor suppressor FRG1 reduces cancerous properties of breast cancer cell lines by regulating ERK pathway, irrespective of molecular subtypes. Cancer Research, 80(16_Supplement), 5969-5969.

Tiwari, A., Mukherjee, B., Hassan, M. K., Pattanaik, N., Jaiswal, A. M., & Dixit, M. (2019). Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion. BMc cancer, 19, 1-15.

Mah, J. K., & Chen, Y. W. (2018). A pediatric review of facioscapulohumeral muscular dystrophy. Journal of Pediatric Neurology, 16(04), 222-231.

Himeda, C. L., Jones, T. I., Virbasius, C. M., Zhu, L. J., Green, M. R., & Jones, P. L. (2018). Identification of epigenetic regulators of DUX4-fl for targeted therapy of facioscapulohumeral muscular dystrophy. Molecular Therapy, 26(7), 1797-1807.

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For research use only. Not intended for any clinical use.

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