FXN Matched Antibody Pair (457) (APMAB-457LY)

Hackett, P. T., Jia, X., Li, L., & Ward, D. M. (2022). Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich’s ataxia. Journal of Biological Chemistry, 298(6).

Medina-Carbonero, M., Sanz-Alcázar, A., Britti, E., Delaspre, F., Cabiscol, E., Ros, J., & Tamarit, J. (2022). Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations. Cellular and Molecular Life Sciences, 79(2), 74.

Culley, M. K., Zhao, J., Tai, Y. Y., Tang, Y., Perk, D., Negi, V., ... & Chan, S. Y. (2021). Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. The Journal of Clinical Investigation, 131(11).

Doni, D., Rigoni, G., Palumbo, E., Baschiera, E., Peruzzo, R., De Rosa, E., ... & Costantini, P. (2021). The displacement of frataxin from the mitochondrial cristae correlates with abnormal respiratory supercomplexes formation and bioenergetic defects in cells of Friedreich ataxia patients. The FASEB Journal, 35(3), e21362.

Li, J., Li, Y., Wang, J., Gonzalez, T. J., Asokan, A., Napierala, J. S., & Napierala, M. (2020). Defining transcription regulatory elements in the human Frataxin gene: implications for gene therapy. Human gene therapy, 31(15-16), 839-851.

Du, J., Zhou, Y., Li, Y., Xia, J., Chen, Y., Chen, S., ... & Wang, Y. (2020). Identification of Frataxin as a regulator of ferroptosis. Redox Biology, 32, 101483.

Maio, N., Jain, A., & Rouault, T. A. (2020). Mammalian iron–sulfur cluster biogenesis: recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins. Current opinion in chemical biology, 55, 34-44.

Patra, S., & Barondeau, D. P. (2019). Mechanism of activation of the human cysteine desulfurase complex by frataxin. Proceedings of the National Academy of Sciences, 116(39), 19421-19430.

Fox, N. G., Yu, X., Feng, X., Bailey, H. J., Martelli, A., Nabhan, J. F., ... & Han, S. (2019). Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. Nature communications, 10(1), 2210.

Britti, E., Delaspre, F., Feldman, A., Osborne, M., Greif, H., Tamarit, J., & Ros, J. (2018). Frataxin‐deficient neurons and mice models of Friedreich ataxia are improved by TAT‐MTS cs‐FXN treatment. Journal of cellular and molecular medicine, 22(2), 834-848.

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-FXN (The first part of exon 4 of frataxin) Recombinant Antibody (CBXF-3243)

Mouse Anti-FXN (AA 91-200) Recombinant Antibody (CBXF-3244)

Rabbit Anti-FXN Recombinant Antibody (CBXF-1223)

Mouse Anti-FXN Recombinant Antibody (CBXF-1812)

Mouse Anti-FXN Recombinant Antibody (CBXF-2266)

Mouse Anti-FXN Recombinant Antibody (CBXF-3245)

Mouse Anti-FXN Recombinant Antibody (CBXF-3733)

Mouse Anti-FXN Recombinant Antibody (5E3)

Mouse Anti-FXN Recombinant Antibody (CBXF-2544)

Mouse Anti-FXN Recombinant Antibody (1E11)

Isotype control