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HMGB2 Matched Antibody Pair (558) (APMAB-558LY)

This antibody pair set can be used for detecting and quantifying protein level of human HMGB2.
See all HMGB2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-HMGB2 monoclonal antibody, 100 ug
Detection Antibody
Anti-HMGB2 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
Alternative Names
High Mobility Group Box 2; High-Mobility Group (Nonhistone Chromosomal) Protein 2; High Mobility Group Protein 2; HMG-2; HMG2; High Mobility Group Protein B2; High-Mobility Group Box 2;
Entrez Gene ID
3148
UniProt ID
P26583

Wang, Y., Yang, Y., Zhang, T., Jia, S., Ma, X., Zhang, M., ... & Ma, A. (2022). LncRNA SNHG16 accelerates atherosclerosis and promotes ox-LDL-induced VSMC growth via the miRNA-22–3p/HMGB2 axis. European Journal of Pharmacology, 915, 174601.

Wang, F., Luo, Y., Zhang, L., Younis, M., & Yuan, L. (2022). The LncRNA RP11-301G19. 1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway. Cancer gene therapy, 29(3-4), 292-303.

Yano, K., Choijookhuu, N., Ikenoue, M., Fidya, Fukaya, T., Sato, K., ... & Hishikawa, Y. (2022). Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration. Scientific Reports, 12(1), 11962.

Pu, J., Tan, C., Shao, Z., Wu, X., Zhang, Y., Xu, Z., ... & Wei, H. (2020). Long noncoding RNA PART1 promotes hepatocellular carcinoma progression via targeting miR-590-3p/HMGB2 axis. OncoTargets and therapy, 9203-9211.

Zhang, X., Dang, Y., Liu, R., Zhao, S., Ma, J., & Qin, Y. (2020). MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. Journal of Cellular Physiology, 235(11), 8826-8838.

Fang, J., Ge, X., Xu, W., Xie, J., Qin, Z., Shi, L., ... & Wang, H. (2020). Bioinformatics analysis of the prognosis and biological significance of HMGB1, HMGB2, and HMGB3 in gastric cancer. Journal of cellular physiology, 235(4), 3438-3446.

Cui, G., Cai, F., Ding, Z., & Gao, L. (2019). HMGB2 promotes the malignancy of human gastric cancer and indicates poor survival outcome. Human pathology, 84, 133-141.

Han, Q., Xu, L., Lin, W., Yao, X., Jiang, M., Zhou, R., ... & Zhao, L. (2019). Long noncoding RNA CRCMSL suppresses tumor invasive and metastasis in colorectal carcinoma through nucleocytoplasmic shuttling of HMGB2. Oncogene, 38(16), 3019-3032.

Fu, D., Li, J., Wei, J., Zhang, Z., Luo, Y., Tan, H., & Ren, C. (2018). HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer. Cell Communication and Signaling, 16, 1-10.

Zirkel, A., Nikolic, M., Sofiadis, K., Mallm, J. P., Brackley, C. A., Gothe, H., ... & Papantonis, A. (2018). HMGB2 loss upon senescence entry disrupts genomic organization and induces CTCF clustering across cell types. Molecular cell, 70(4), 730-744.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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