HSPB1 Matched Antibody Pair (577) (APMAB-577LY)

Name: HSPB1 Matched Antibody Pair (577)
SKU: APMAB-577LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-HSPB1 monoclonal antibody, 100 ug

Detection Antibody

Anti-HSPB1 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Alternative Names

Heat Shock Protein Family B (Small) Member 1; Estrogen-Regulated 24 KDa Protein; Stress-Responsive Protein 27; Heat Shock 27kDa Protein 1; Heat Shock 27kD Protein 1; Heat Shock 27 KDa Protein; 28 KDa Heat Shock Protein; HSP27; HSP28; SRP27;

Entrez Gene ID

3315

UniProt ID

P04792

More Infomation

Wang, L., Wu, S., He, H., Ai, K., Xu, R., Zhang, L., & Zhu, X. (2022). CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. Laboratory Investigation, 102(12), 1323-1334.

Lu, S., Hu, J., Arogundade, O. A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J. K., ... & Cleveland, D. W. (2022). Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nature cell biology, 24(9), 1378-1393.

Alexander, C. C., Munkáscy, E., Tillmon, H., Fraker, T., Scheirer, J., Holstein, D., ... & Rodriguez, K. A. (2022). HspB1 overexpression improves life span and stress resistance in an invertebrate model. The Journals of Gerontology: Series A, 77(2), 268-275.

Liu, X., Xiao, W., Jiang, Y., Zou, L., Chen, F., Xiao, W., ... & Zhu, Y. (2021). Bmal1 regulates the redox rhythm of HSPB1, and homooxidized HSPB1 attenuates the oxidative stress injury of cardiomyocytes. Oxidative Medicine and Cellular Longevity, 2021, 1-16.

Gonçalves, C. C., Sharon, I., Schmeing, T. M., Ramos, C. H., & Young, J. C. (2021). The chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70. Scientific reports, 11(1), 17139.

Muranova, L. K., Sudnitsyna, M. V., Strelkov, S. V., & Gusev, N. B. (2020). Mutations in HspB1 and hereditary neuropathies. Cell Stress and Chaperones, 25, 655-665.

Baughman, H. E., Pham, T. H. T., Adams, C. S., Nath, A., & Klevit, R. E. (2020). Release of a disordered domain enhances HspB1 chaperone activity toward tau. Proceedings of the National Academy of Sciences, 117(6), 2923-2929.

Haidar, M., Asselbergh, B., Adriaenssens, E., De Winter, V., Timmermans, J. P., Auer-Grumbach, M., ... & Timmerman, V. (2019). Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy, 15(6), 1051-1068.

Wang, Y., Liu, J., Kong, Q., Cheng, H., Tu, F., Yu, P., ... & Liu, L. (2019). Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFκB-mediated leucocyte recruitment after myocardial infarction. Cardiovascular research, 115(1), 154-167.

Baughman, H. E., Clouser, A. F., Klevit, R. E., & Nath, A. (2018). HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation. Journal of Biological Chemistry, 293(8), 2687-2700.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant HSPB1 protein, GST Tag (CAT#: V2LY-0526-LY4588)

Human Recombinant HSPB1 protein, His Tag (CAT#: V2LY-0526-LY4589)

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Isotype control

For research use only. Not intended for any clinical use.

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