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HSPD1 Matched Antibody Pair (578) (APMAB-578LY)

This antibody pair set can be used for detecting and quantifying protein level of human HSPD1.
See all HSPD1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HSPD1 polyclonal antibody, 100 ug
Detection Antibody
Anti-HSPD1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
Alternative Names
Heat Shock Protein Family D (Hsp60) Member 1; Heat Shock 60kDa Protein 1 (Chaperonin); Mitochondrial Matrix Protein P1; P60 Lymphocyte Protein; 0 KDa Chaperonin; Chaperonin 60; HuCHA60; HSP-60; HSP60; CPN60; Spastic Paraplegia 13 (Autosomal Dominant);
Entrez Gene ID
3329
UniProt ID
P10809

Duan, Y., Yu, J., Chen, M., Lu, Q., Ning, F., Gan, X., ... & Lash, G. E. (2023). Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). Journal of ovarian research, 16(1), 1-14.

Zheng, X., Chang, S., Liu, Y., Dai, X., & You, C. (2023). Human Mitochondrial Protein HSPD1 Binds to and Regulates the Repair of Deoxyinosine in DNA. Journal of Proteome Research, 22(4), 1339-1346.

Wu, T., Jia, L., Lei, S., Jiang, H., Liu, J., Li, N., ... & Lei, L. (2022). Host HSPD1 Translocation from Mitochondria to the Cytoplasm Induced by Streptococcus suis Serovar 2 Enolase Mediates Apoptosis and Loss of Blood–Brain Barrier Integrity. Cells, 11(13), 2071.

Song, X., Chen, B., Liang, Y., Li, Y., Zhang, H., Han, D., ... & Yang, Q. (2022). CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA. Cell Death Discovery, 8(1), 261.

Parma, B., Ramesh, V., Gollavilli, P. N., Siddiqui, A., Pinna, L., Schwab, A., ... & Ceppi, P. (2021). Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. Journal of Experimental & Clinical Cancer Research, 40(1), 1-20.

Klebl, D. P., Feasey, M. C., Hesketh, E. L., Ranson, N. A., Wurdak, H., Sobott, F., ... & Muench, S. P. (2021). Cryo-EM structure of human mitochondrial HSPD1. Iscience, 24(1).

Albadawy, R., Agwa, S. H., Khairy, E., Saad, M., El Touchy, N., Othman, M., & Matboli, M. (2021). Clinical significance of hspd1/mmp14/itgb1/mir-6881-5p/lnc-sparcl1-1: 2 rna panel in nafld/nash diagnosis: Egyptian pilot study. Biomedicines, 9(9), 1248.

Cömert, C., Brick, L., Ang, D., Palmfeldt, J., Meaney, B. F., Kozenko, M., ... & Bross, P. (2020). A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy. Molecular Case Studies, 6(3), a004879.

Kang, B. H., Shu, C. W., Chao, J. K., Lee, C. H., Fu, T. Y., Liou, H. H., ... & Liu, P. F. (2019). HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma. Scientific reports, 9(1), 8932.

Kim, S. K., Kim, K., Ryu, J. W., Ryu, T. Y., Lim, J. H., Oh, J. H., ... & Cho, H. S. (2019). The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer. International Journal of Oncology, 54(1), 65-76.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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