Human BCL11A ELISA Kit (V2LY-0626-LY11)

Name: Human BCL11A ELISA Kit
SKU: V2LY-0626-LY11
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0035 ng/mL

Detection Range

0.007-1.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

91.2 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

B Cell CLL/Lymphoma 11A

Function

Transcription factor (PubMed:16704730, PubMed:29606353).
Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491).
Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353).
Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765).
Involved in brain development (PubMed:27453576).
May play a role in hematopoiesis (By similarity).
Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).
May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).

Biological Process

Cellular response to L-glutamate Source: Ensembl
Negative regulation of axon extension Source: BHF-UCL
Negative regulation of branching morphogenesis of a nerve Source: Ensembl
Negative regulation of collateral sprouting Source: BHF-UCL
Negative regulation of dendrite development Source: BHF-UCL
Negative regulation of dendrite extension Source: Ensembl
Negative regulation of neuron projection development Source: BHF-UCL
Negative regulation of neuron remodeling Source: Ensembl
Negative regulation of protein homooligomerization Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of collateral sprouting Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein sumoylation Source: UniProtKB
Regulation of dendrite development Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm; Nucleus; Chromosome. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity).
Isoform 1: Nucleus matrix. Colocalizes with BCL6 in nuclear paraspeckles.
Isoform 2: Cytoplasm; Nucleus. Predominantly localized in the nucleus in nuclear paraspeckles.
Isoform 3: Cytoplasm; Nucleus. Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.

Involvement in disease

Chromosomal aberrations involving BCL11A are associated with B-cell malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and overexpression.
Intellectual developmental disorder with persistence of fetal hemoglobin (IDPFH): An autosomal dominant disorder characterized by delayed psychomotor development, intellectual disability, variable dysmorphic features, including microcephaly, downslanting palpebral fissures, strabismus, and external ear abnormalities, and asymptomatic persistence of fetal hemoglobin.

PTM

Sumoylated with SUMO1.

Simon, R., Wiegreffe, C., & Britsch, S. (2020). Bcl11 transcription factors regulate cortical development and function. Frontiers in molecular neuroscience, 13, 51.

Chakraborty, S. (2019). Amplicon-sequencing of BCL11a-edited stem cells used to treat beta thalassemia and sickle cell disease suffices to demonstrate that CRISPR is a chromosome shredder.

Peron, A., Bradbury, K., Viskochil, D. H., & Dias, C. (2019). BCL11A-related intellectual disability.

Mathies, L. D., Aliev, F., COGA Investigators, Davies, A. G., Dick, D. M., Bettinger, J. C., ... & Reilly, M. (2017). Variation in SWI/SNF chromatin remodeling complex proteins is associated with alcohol dependence and antisocial behavior in human populations. Alcoholism: Clinical and Experimental Research, 41(12), 2033-2040.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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