Human CAP2 ELISA Kit (V2LY-0626-LY5638)

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Tested Data
Request for COA
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Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
52.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
CAP, adenylate cyclase-associated protein, 2 (yeast)
Function
May have a regulatory bifunctional role.
Biological Process
Activation of adenylate cyclase activity
cAMP-mediated signaling
Cell morphogenesis
Cytoskeleton organization
Establishment or maintenance of cell polarity
Regulation of adenylate cyclase activity
Signal transduction
Cellular Location
Cell membrane

Kepser, L. J., Khudayberdiev, S., Hinojosa, L. S., Macchi, C., Ruscica, M., Marcello, E., ... & Rust, M. B. (2021). Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts. Scientific reports, 11(1), 1-12.

Wan, Y., Qiu, S., Yin, L., Gao, X., Jiang, Y., Feng, S., & Tang, C. (2021). CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9. Journal of Gastrointestinal Oncology, 12(2), 268.

Schneider, F., Metz, I., Khudayberdiev, S., & Rust, M. B. (2021). Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons. Cells, 10(6), 1525.

Adachi, M., Masugi, Y., Yamazaki, K., Emoto, K., Kobayashi, Y., Tominaga, E., ... & Sakamoto, M. (2020). Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes. Japanese journal of clinical oncology, 50(6), 643-652.

Kepser, L. J. (2020). The Role of the Actin Regulator Cyclase-associated Protein 2 (CAP2) for Mammalian Skeletal Muscle Development (Doctoral dissertation, Philipps-Universität Marburg).

Saker, Z., Bahmad, H. F., Fares, Y., Al Najjar, Z., Saad, M., Harati, H., & Nabha, S. (2020). Prognostic impact of adenylyl cyclase-associated protein 2 (CAP2) in glioma: a clinicopathological study. Heliyon, 6(1), e03236.

Kepser, L. J., Damar, F., De Cicco, T., Chaponnier, C., Prószyński, T. J., Pagenstecher, A., & Rust, M. B. (2019). CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proceedings of the National Academy of Sciences, 116(17), 8397-8402.

Aspit, L., Levitas, A., Etzion, S., Krymko, H., Slanovic, L., Zarivach, R., ... & Parvari, R. (2019). CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy. Journal of medical genetics, 56(4), 228-235.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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