Human ADAMTS18 ELISA Kit (V2LY-0626-LY4304)

Name: Human ADAMTS18 ELISA Kit
SKU: V2LY-0626-LY4304
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

1.16 ng/mL

Detection Range

3-900 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

135.2 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

ADAM Metallopeptidase With Thrombospondin Type 1 Motif 18

Biological Process

Extracellular matrix organization
Eye development
Negative regulation of platelet aggregation

Cellular Location

Extracellular matrix

Involvement in disease

Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT): A ocular syndrome characterized by microcornea and myopic chorioretinal atrophy. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. In addition to ocular findings, some patients have telecanthus and posteriorly rotated ears.

PTM

The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Ye, S., Yang, N., Lu, T., Wu, T., Wang, L., Pan, Y. H., ... & Zhang, W. (2021). Adamts18 modulates the development of aortic arch and common carotid artery. Available at SSRN 3780285.

Jiang, K., Li, L., Xie, Y., Xie, D., & Xiao, Q. (2020). High ADAMTS18 expression is associated with poor prognosis in stomach adenocarcinoma. Oncology Letters, 20(5), 1-1.

Ataca, D., Aouad, P., Constantin, C., Laszlo, C., Beleut, M., Shamseddin, M., ... & Brisken, C. (2020). The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche. Nature communications, 11(1), 1-16.

Lu, T., Lin, X., Pan, Y. H., Yang, N., Ye, S., Zhang, Q., ... & Zhang, W. (2020). ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation. Iscience, 23(9), 101472.

Zhu, R., Cheng, M., Lu, T., Yang, N., Ye, S., Pan, Y. H., ... & Zhang, W. (2018). A disintegrin and metalloproteinase with thrombospondin motifs 18 deficiency leads to visceral adiposity and associated metabolic syndrome in mice. The American journal of pathology, 188(2), 461-473.

Guo, X., Li, J., Zhang, H., Liu, H., Liu, Z., & Wei, X. (2018). Relationship between ADAMTS8, ADAMTS18, and ADAMTS20 (a disintegrin and metalloproteinase with thrombospondin motifs) expressions and tumor molecular classification, clinical pathological parameters, and prognosis in breast invasive ductal carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 3726.

Zhang, L., Liu, Y., & Zheng, P. (2018). Downregulation of ADAMTS18 May serve as a poor prognostic biomarker for cervical cancer patients. Applied immunohistochemistry & molecular morphology, 26(9), 670-675.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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