Human DCC ELISA Kit (V2LY-0626-LY4093)

Name: Human DCC ELISA Kit
SKU: V2LY-0626-LY4093
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.011 ng/mL

Detection Range

0.02-6 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

158.5 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

DCC Netrin 1 Receptor

Function

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Biological Process

Anterior/posterior axon guidance Source: Ensembl
Apoptotic process Source: ProtInc
Axon guidance Source: Reactome
Axonogenesis Source: ProtInc
Dorsal/ventral axon guidance Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
Negative regulation of collateral sprouting Source: BHF-UCL
Negative regulation of dendrite development Source: BHF-UCL
Negative regulation of netrin-activated signaling pathway Source: Reactome
Negative regulation of neuron projection development Source: BHF-UCL
Neuron migration Source: Ensembl
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Regulation of neuron death Source: UniProtKB
Spinal cord ventral commissure morphogenesis Source: Ensembl

Cellular Location

Membrane

Involvement in disease

Mirror movements 1 (MRMV1):
A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Some MRMV1 patients have agenesis of the corpus callosum.
Gaze palsy, familial horizontal, with progressive scoliosis, 2, with impaired intellectual development (HGPPS2):
An autosomal recessive neurologic disorder characterized by global developmental delay, delayed walking, intellectual disability, horizontal gaze palsy, and childhood-onset progressive scoliosis.

Topology

Extracellular: 26-1097
Helical: 1098-1122
Cytoplasmic: 1123-1447

PTM

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

Chen, G., Kang, S. S., Wang, Z., Ahn, E. H., Xia, Y., Liu, X., ... & Ye, K. (2021). Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies. Science advances, 7(16), eabe4499.

Li, H. J., Qu, N., Hui, L., Cai, X., Zhang, C. Y., Zhong, B. L., ... & Li, Y. (2020). Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Translational psychiatry, 10(1), 1-15.

Vosberg, D. E., Leyton, M., & Flores, C. (2020). The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence. Molecular psychiatry, 25(2), 297-307.

Torres-Berrío, A., Hernandez, G., Nestler, E. J., & Flores, C. (2020). The Netrin-1/DCC guidance cue pathway as a molecular target in depression: translational evidence. Biological Psychiatry, 88(8), 611-624.

Kang, D. S., Yang, Y. R., Lee, C., Park, B., Park, K. I., Seo, J. K., ... & Suh, P. G. (2018). Netrin‐1/DCC‐mediated PLC γ1 activation is required for axon guidance and brain structure development. EMBO reports, 19(11), e46250.

Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H. D., Svergun, D. I., ... & Meijers, R. (2018). Structural basis for Draxin-Modulated Axon guidance and fasciculation by Netrin-1 through DCC. Neuron, 97(6), 1261-1267.

Torres-Vega, E., Mancheño, N., Cebrián-Silla, A., Herranz-Pérez, V., Chumillas, M. J., Moris, G., ... & Bataller, L. (2017). Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis. Neurology, 88(13), 1235-1242.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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